STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
cobBNAD-dependent deacetylase; COG0846; Belongs to the sirtuin family. Class III subfamily. (251 aa)    
Predicted Functional Partners:
CL1_1539
Archaeal nicotinamide-nucleotide adenylyltransferase; COG1056.
   
 
  0.950
nadE
Putative NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.926
nadK
NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.923
CL1_0684
Pyrazinamidase/nicotinamidase-like protein; COG1335.
   
 0.920
CL1_1872
Hypothetical protein.
       0.916
CL1_1873
Hypothetical protein; COG1011.
   
   0.882
CL1_1874
Hypothetical protein; COG2411.
       0.878
CL1_0542
Glutamate dehydrogenase; COG0334; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.825
CL1_1412
Putative histone deacetylase; COG0123.
   
 0.813
CL1_1875
Hypothetical protein containing Phosphatidic acid phosphatase type 2 domain; COG0671.
     
 0.812
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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