STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_1971Glycosyl transferase family 2 protein 3; COG0463. (222 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
  
    0.819
CL1_1975
Hypothetical protein containing archease domain; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
  
    0.647
rtcB
Hypothetical protein; COG1372; Belongs to the RtcB family.
  
    0.635
CL1_1976
tRNA/rRNA cytosine-C5-methylase; COG0144; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
       0.634
CL1_1977
Hypothetical protein; COG3270.
       0.634
CL1_0858
Lps biosynthesis rfbU-like protein; COG0438.
 
  
 0.594
CL1_1973
Hypothetical protein.
       0.592
CL1_1974
Hypothetical protein containing PIN domain 19; COG4113.
       0.592
CL1_0748
Glycosyl transferase family 2 protein 2; COG0463.
 
  
0.590
CL1_1599
Glycosyl transferase family protein 4; COG0438.
 
  
 0.569
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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