STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CL1_1987Putative Mn2+-dependent serine/threonine protein kinase; COG3642. (222 aa)    
Predicted Functional Partners:
kae1
Putative DNA-binding/iron metalloprotein/AP endonuclease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
   
 0.951
CL1_1988
Hypothetical protein; COG0620.
       0.818
CL1_1989
Chaperonin subunit alpha; COG0459; Belongs to the TCP-1 chaperonin family.
 
  
 0.707
CL1_1465
Hypothetical protein; COG1617.
    
 
 0.681
rps15
30S ribosomal protein S15; COG0184.
 
   
 0.539
map
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
 
  
 0.499
infB
Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
 
  
 0.491
CL1_0824
Hypothetical protein containing Trimeric LpxA-like domain; COG0110.
     
 0.470
CL1_1720
Putative Serine/threonine protein phosphatase; COG0631.
 
 
 0.463
htpX
Putative heat shock protein HtpX 1; COG0501; Belongs to the peptidase M48B family.
       0.462
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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