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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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CL1_1989Chaperonin subunit alpha; COG0459; Belongs to the TCP-1 chaperonin family. (553 aa)    
Predicted Functional Partners:
htpX
Putative heat shock protein HtpX 1; COG0501; Belongs to the peptidase M48B family.
  
 0.886
pfdA-2
Prefoldin alpha subunit 2; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
   
 0.868
CL1_1987
Putative Mn2+-dependent serine/threonine protein kinase; COG3642.
 
  
 0.866
CL1_0151
Putative ATP-dependent protease Lon; COG1067; Belongs to the peptidase S16 family.
 
 0.819
tbp
TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
 
 
 0.788
fusA
Elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
 
 
 0.736
eif5a
Translation initiation factor IF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
 
 
 0.704
rpl4
50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel.
 
 
 0.690
CL1_1720
Putative Serine/threonine protein phosphatase; COG0631.
   
 
 0.682
psmA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 
 0.678
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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