STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_1989Chaperonin subunit alpha; COG0459; Belongs to the TCP-1 chaperonin family. (553 aa)    
Predicted Functional Partners:
tbp
TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
 
 
 0.797
eif5a
Translation initiation factor IF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
 
 
 0.748
CL1_1898
Amino acid transporter; COG0531.
  
 
 0.719
infB
Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
  
 
 0.712
CL1_1987
Putative Mn2+-dependent serine/threonine protein kinase; COG3642.
 
  
 0.707
CL1_0151
Putative ATP-dependent protease Lon; COG1067; Belongs to the peptidase S16 family.
 
 
 0.705
htpX
Putative heat shock protein HtpX 1; COG0501; Belongs to the peptidase M48B family.
  
 
 0.705
fusA
Elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
 
 
 0.703
rpl4
50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel.
 
 
 0.690
eif2g
Translation initiation factor IF-2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
 
  
 0.681
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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