Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_1997Hypothetical protein containing isochorismatase domain; COG1535. (210 aa)    
Predicted Functional Partners:
CL1_1995
Hypothetical protein; COG0820.
 
     0.870
CL1_1996
Putative pyridine nucleotide-disulfide oxidoreductase; COG0492.
 
    0.853
CL1_1998
Glucose-1-dehydrogenase; COG1028.
  
 
 0.772
CL1_1994
Putative nucleotidyltransferase; COG1708.
       0.637
CL1_1993
Hypothetical protein; COG2445.
       0.631
CL1_1355
Nicotinate phosphoribosyltransferase; COG1488.
 
  
 0.533
hisI
Hypothetical protein; COG0139; In the N-terminal section; belongs to the PRA-CH family.
  
    0.507
dys
Putative deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
       0.493
CL1_1898
Amino acid transporter; COG0531.
 
  
 0.414
CL1_0744
Putative carbon-nitrogen hydrolase; COG0388.
 
 
 0.403
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
Server load: low (8%) [HD]