Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CL1_1998Glucose-1-dehydrogenase; COG1028. (239 aa)    
Predicted Functional Partners:
CL1_1996
Putative pyridine nucleotide-disulfide oxidoreductase; COG0492.
  
  
 0.855
CL1_1995
Hypothetical protein; COG0820.
  
  
 0.845
dys
Putative deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
     
 0.831
CL1_1997
Hypothetical protein containing isochorismatase domain; COG1535.
  
 
 0.772
CL1_1994
Putative nucleotidyltransferase; COG1708.
       0.765
CL1_1404
acetyl-CoA acetyltransferase; COG0183.
 
 
 0.695
mre11
DNA double-strand break repair protein mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
  
 
 0.651
CL1_1601
Asparagine synthase; COG0367.
 
 
 
 0.621
CL1_1144
Putative glutamate synthase subunit beta; COG0493.
     
 0.591
CL1_1993
Hypothetical protein; COG2445.
       0.578
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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