Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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cobSPutative cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (233 aa)    
Predicted Functional Partners:
CL1_2016
Hypothetical protein; COG2266.
 
  
  0.978
CL1_2020
Putative phosphatidylglycerophosphatase A; COG1267.
 
  
 0.967
cobD
Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
   
 0.967
CL1_1183
Putative cob(I)alamin adenosyltransferase; COG2109.
 
 
 0.963
CL1_0082
Cobalamin adenosyltransferase like protein; COG2096.
    
 0.927
CL1_2021
Hypothetical protein.
       0.916
CL1_2024
Putative aminotransferase 1; COG0079.
 
   
 0.909
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.905
CL1_2022
Putative uracil-DNA glycosylase; COG1573.
  
  
 0.852
CL1_2013
Hypothetical protein; COG2038; Belongs to the UPF0284 family.
 
  
 0.730
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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