STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (294 aa)    
Predicted Functional Partners:
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
 
 0.987
cobS
Putative cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
   
 0.967
CL1_1183
Putative cob(I)alamin adenosyltransferase; COG2109.
 
  
 0.963
CL1_2024
Putative aminotransferase 1; COG0079.
 
   
 0.954
CL1_2012
Putative adenosylcobinamide amidohydrolase; COG1865.
 
  
  0.951
CL1_2016
Hypothetical protein; COG2266.
 
  
  0.946
CL1_0082
Cobalamin adenosyltransferase like protein; COG2096.
 
  
 0.931
CL1_2022
Putative uracil-DNA glycosylase; COG1573.
       0.916
CL1_2025
S-adenosyl-L-methionine-dependent methyltransferase; COG0500.
  
    0.883
CL1_2020
Putative phosphatidylglycerophosphatase A; COG1267.
 
   
 0.871
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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