STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANP27838.1Pfam: Hydroxymethylglutaryl-coenzyme A synthase N terminal; TIGRFAM: HMG-CoA-S_prok: hydroxymethylglutaryl-CoA synthase; Pfam: Hydroxymethylglutaryl-coenzyme A synthase C terminal. (386 aa)    
Predicted Functional Partners:
ANP27839.1
hydroxymethylglutaryl-CoA reductase (NADPH); PRINTS: Hydroxymethylglutaryl-coenzyme A reductase signature; Pfam: Hydroxymethylglutaryl-coenzyme A reductase.
 
 
 0.999
ANP27842.1
TIGRFAM: mevDPdecarb: diphosphomevalonate decarboxylase; Pfam: GHMP kinases N terminal domain.
 
 
 0.982
ANP27841.1
Pfam: GHMP kinases N terminal domain; PRINTS: Mevalonate kinase family signature; TIGRFAM: Pmev_kin_Gr_pos: phosphomevalonate kinase; Pfam: GHMP kinases C terminal.
 
  
 0.970
ANP27843.1
TIGRFAM: mevalon_kin: mevalonate kinase; PRINTS: Mevalonate kinase family signature; Pfam: GHMP kinases C terminal; Pfam: GHMP kinases N terminal domain.
 
  
 0.970
fni
Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
 0.962
ANP27130.1
Formate acetyltransferase; Pfam: Glycine radical.
    
  0.900
ANP27131.1
Pfam: Glycine radical; Pfam: Pyruvate formate lyase.
    
  0.900
ANP27264.1
PRINTS: Citrate synthase signature; TIGRFAM: cit_synth_I: citrate (Si)-synthase; Pfam: Citrate synthase; Belongs to the citrate synthase family.
    
 0.818
sucD
succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
     
 0.817
sucC
succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 
 0.808
Your Current Organism:
Dermabacter vaginalis
NCBI taxonomy Id: 1630135
Other names: D. vaginalis, DSM 100050, Dermabacter sp. AD1-86, Dermabacter vaginalis Chang et al. 2016, KCTC 39585, strain AD1-86
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