STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (351 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 0.999
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
ANP27859.1
Pfam: Small subunit of acetolactate synthase; TIGRFAM: acolac_sm: acetolactate synthase, small subunit; Pfam: ACT domain.
  
 0.992
ANP27860.1
Acetolactate synthase, large subunit, biosynthetic type; Pfam: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Pfam: Thiamine pyrophosphate enzyme, central domain; Pfam: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; TIGRFAM: acolac_lg: acetolactate synthase, large subunit, biosynthetic type.
 0.992
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.975
ilvD
TIGRFAM: ilvD: dihydroxy-acid dehydratase; Pfam: Dehydratase family; Belongs to the IlvD/Edd family.
  
  
 0.932
ANP27855.1
TIGRFAM: LeuA_rel: 2-isopropylmalate synthase/homocitrate synthase family protein; Pfam: HMGL-like; SMART: LeuA allosteric (dimerisation) domain; Pfam: LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.923
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 
 0.922
ANP27856.1
TIGRFAM: ilvE_II: branched-chain amino acid aminotransferase; Pfam: Aminotransferase class IV.
  
  
 0.864
ANP27264.1
PRINTS: Citrate synthase signature; TIGRFAM: cit_synth_I: citrate (Si)-synthase; Pfam: Citrate synthase; Belongs to the citrate synthase family.
  
 0.682
Your Current Organism:
Dermabacter vaginalis
NCBI taxonomy Id: 1630135
Other names: D. vaginalis, DSM 100050, Dermabacter sp. AD1-86, Dermabacter vaginalis Chang et al. 2016, KCTC 39585, strain AD1-86
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