STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfpHypothetical protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (406 aa)    
Predicted Functional Partners:
pgi
Pfam: Phosphoglucose isomerase; PRINTS: Glucose-6-phosphate isomerase signature; Belongs to the GPI family.
  
 0.977
ANP28414.1
Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.
 
 
 0.951
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
  
 
 0.931
ANP27684.1
Pfam: Transketolase, C-terminal domain; Pfam: Transketolase, pyrimidine binding domain; SMART: Transketolase, pyrimidine binding domain; Pfam: Transketolase, thiamine diphosphate binding domain; TIGRFAM: tktlase_bact: transketolase; Belongs to the transketolase family.
  
 
 0.925
ANP27161.1
Hypothetical protein; Pfam: pfkB family carbohydrate kinase; PRINTS: Ribokinase signature; Belongs to the carbohydrate kinase PfkB family.
  
 
 0.910
ANP26700.1
Mannose-6-phosphate isomerase, class I; PRINTS: Phosphomannose isomerase type I signature; TIGRFAM: manA: mannose-6-phosphate isomerase, class I; Pfam: Phosphomannose isomerase type I.
    
 0.908
pfkA
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
     
 
0.900
ANP27713.1
Pfam: Pyruvate kinase, barrel domain; TIGRFAM: pyruv_kin: pyruvate kinase; PRINTS: Pyruvate kinase family signature; Pfam: Pyruvate kinase, alpha/beta domain; Belongs to the pyruvate kinase family.
  
 
 0.777
eno
Enolase 1; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
  
 0.768
ANP27320.1
TIGRFAM: PTS-II-BC-nag: PTS system, N-acetylglucosamine-specific IIBC component; TIGRFAM: PTBA: PTS system, glucose subfamily, IIA component; TIGRFAM: EIIB_glc: PTS system, glucose-like IIB component; Pfam: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1; Pfam: phosphotransferase system, EIIB; Pfam: Phosphotransferase system, EIIC.
     
 0.761
Your Current Organism:
Dermabacter vaginalis
NCBI taxonomy Id: 1630135
Other names: D. vaginalis, DSM 100050, Dermabacter sp. AD1-86, Dermabacter vaginalis Chang et al. 2016, KCTC 39585, strain AD1-86
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