AMV17114.1 protein (Planctomyces sp. SHPL14)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AMV17114.1

Neutral/alkaline non-lysosomal ceramidase. (451 aa)

Predicted Functional Partners:

nagA

0.823

AMV20370.1

0.771

AMV16670.1

0.768

AMV19552.1

0.768

AMV20221.1

0.765

iolG_1

0.762

AMV19467.1

0.748

AMV19462.1

0.747

AMV17044.1

0.743

AMV18119.1

0.737

Your Current Organism:

Planctomyces sp. SHPL14

NCBI taxonomy Id: 1632864
Other names: P. sp. SH-PL14, Planctomyces sp. SH-PL14

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMV16670.1	AMV17044.1	VT03_02195	VT03_04080	Xylose isomerase-like TIM barrel.	Hypothetical protein.	0.621
AMV16670.1	AMV17114.1	VT03_02195	VT03_04435	Xylose isomerase-like TIM barrel.	Neutral/alkaline non-lysosomal ceramidase.	0.768
AMV16670.1	AMV18119.1	VT03_02195	VT03_09535	Xylose isomerase-like TIM barrel.	Hypothetical protein.	0.417
AMV16670.1	AMV19462.1	VT03_02195	VT03_16330	Xylose isomerase-like TIM barrel.	Alpha/beta hydrolase family protein.	0.752
AMV16670.1	AMV20221.1	VT03_02195	VT03_20155	Xylose isomerase-like TIM barrel.	Prolyl oligopeptidase family protein.	0.716
AMV16670.1	iolG_1	VT03_02195	VT03_00435	Xylose isomerase-like TIM barrel.	Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase.	0.518
AMV17044.1	AMV16670.1	VT03_04080	VT03_02195	Hypothetical protein.	Xylose isomerase-like TIM barrel.	0.621
AMV17044.1	AMV17114.1	VT03_04080	VT03_04435	Hypothetical protein.	Neutral/alkaline non-lysosomal ceramidase.	0.743
AMV17044.1	AMV18119.1	VT03_04080	VT03_09535	Hypothetical protein.	Hypothetical protein.	0.876
AMV17044.1	AMV19462.1	VT03_04080	VT03_16330	Hypothetical protein.	Alpha/beta hydrolase family protein.	0.741
AMV17044.1	AMV19467.1	VT03_04080	VT03_16355	Hypothetical protein.	Hypothetical protein.	0.537
AMV17044.1	AMV19552.1	VT03_04080	VT03_16780	Hypothetical protein.	Cytochrome c.	0.563
AMV17044.1	AMV20370.1	VT03_04080	VT03_20905	Hypothetical protein.	Cytochrome c.	0.701
AMV17044.1	iolG_1	VT03_04080	VT03_00435	Hypothetical protein.	Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase.	0.725
AMV17114.1	AMV16670.1	VT03_04435	VT03_02195	Neutral/alkaline non-lysosomal ceramidase.	Xylose isomerase-like TIM barrel.	0.768
AMV17114.1	AMV17044.1	VT03_04435	VT03_04080	Neutral/alkaline non-lysosomal ceramidase.	Hypothetical protein.	0.743
AMV17114.1	AMV18119.1	VT03_04435	VT03_09535	Neutral/alkaline non-lysosomal ceramidase.	Hypothetical protein.	0.737
AMV17114.1	AMV19462.1	VT03_04435	VT03_16330	Neutral/alkaline non-lysosomal ceramidase.	Alpha/beta hydrolase family protein.	0.747
AMV17114.1	AMV19467.1	VT03_04435	VT03_16355	Neutral/alkaline non-lysosomal ceramidase.	Hypothetical protein.	0.748
AMV17114.1	AMV19552.1	VT03_04435	VT03_16780	Neutral/alkaline non-lysosomal ceramidase.	Cytochrome c.	0.768

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034654

Nucleobase-containing compound biosynthetic process

10 of 150

1.39

2.51

4.19e-12

GO:0006796

Phosphate-containing compound metabolic process

10 of 293

1.1

1.48

1.77e-09

GO:0044237

Cellular metabolic process

11 of 1599

0.4

0.34

0.00091

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

9 of 10

2.52

8.24

4.91e-18

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

2 of 3

2.39

1.33

0.0034

GO:0003824

Catalytic activity

11 of 2004

0.3

0.25

0.0178

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045259

Proton-transporting ATP synthase complex

9 of 9

2.56

8.79

4.58e-19

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.56

4.87

3.47e-10

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

4 of 4

2.56

3.87

3.98e-08

GO:0032991

Protein-containing complex

10 of 227

1.21

1.83

1.41e-10

GO:0005886

Plasma membrane

9 of 557

0.77

0.74

1.24e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:308

ATP synthesis

10 of 11

2.52

9.31

1.11e-20

CL:311

Proton-transporting ATP synthase complex, catalytic core F(1)

6 of 6

2.56

5.68

6.37e-12

CL:132

Ribosome, and ATP synthesis

11 of 99

1.61

3.76

1.67e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lmd00190

Oxidative phosphorylation

10 of 48

1.88

5.23

2.10e-16

lmd01100

Metabolic pathways

9 of 810

0.61

0.49

0.0012

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

9 of 10

2.52

8.4

2.00e-18

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.56

4.65

9.98e-10

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

4 of 5

2.47

3.49

1.92e-07

GOCC:0032991

Protein-containing complex

10 of 545

0.83

0.86

8.33e-07

GOCC:0005622

Intracellular

11 of 1572

0.41

0.35

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0066

ATP synthesis

9 of 9

2.56

8.71

7.31e-19

KW-0375

Hydrogen ion transport

9 of 11

2.48

8.35

1.26e-18

KW-0139

CF(1)

5 of 5

2.56

4.72

6.94e-10

KW-0138

CF(0)

4 of 4

2.56

3.77

6.35e-08

KW-1003

Cell membrane

9 of 203

1.21

1.73

4.60e-09

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02874

ATP synthase alpha/beta family, beta-barrel domain

2 of 2

2.56

0.91

0.0224

PF00430

ATP synthase B/B CF(0)

2 of 2

2.56

0.91

0.0224

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