STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OSY88342.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (475 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.961
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.942
OSY89103.1
Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.929
OSY88089.1
Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.926
OSY88083.1
Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.924
thrB
Serine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.923
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
  0.923
OSY89100.1
Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
  0.922
OSY88170.1
Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.849
OSY87870.1
Aminotransferase class V; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.803
Your Current Organism:
Tenacibaculum holothuriorum
NCBI taxonomy Id: 1635173
Other names: LMG 27758, LMG:27758, MCCC 1A09872, T. holothuriorum, Tenacibaculum holothuriorum Wang et al. 2015, Tenacibaculum sp. S2-2, strain S2-2
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