node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KRT63976.1 | KRT65949.1 | XU11_C0059G0014 | XU11_C0016G0018 | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Cyclic nucleotide-binding protein. | 0.594 |
KRT63976.1 | KRT65993.1 | XU11_C0059G0014 | XU11_C0015G0010 | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Cell division protein FtsK/SpoIIIE, DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family. | 0.686 |
KRT63976.1 | KRT66065.1 | XU11_C0059G0014 | XU11_C0014G0027 | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.933 |
KRT63976.1 | apt | XU11_C0059G0014 | XU11_C0011G0058 | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Adenine phosphoribosyltransferase, adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.624 |
KRT63976.1 | gdhA | XU11_C0059G0014 | XU11_C0028G0036 | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Glutamate dehydrogenase, glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.671 |
KRT63976.1 | guaB | XU11_C0059G0014 | XU11_C0035G0026 | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.757 |
KRT63976.1 | murC | XU11_C0059G0014 | XU11_C0002G0067 | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.780 |
KRT63976.1 | murD | XU11_C0059G0014 | XU11_C0002G0064 | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | UDP-N-acetylmuramoylalanine--D-glutamate ligase, UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.850 |
KRT63976.1 | murE | XU11_C0059G0014 | XU11_C0002G0061 | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.798 |
KRT63976.1 | murF | XU11_C0059G0014 | XU11_C0002G0062 | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | UDP-N-acetylmuramyl-tripeptide synthetase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.769 |
KRT65949.1 | KRT63976.1 | XU11_C0016G0018 | XU11_C0059G0014 | Cyclic nucleotide-binding protein. | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.594 |
KRT65949.1 | gdhA | XU11_C0016G0018 | XU11_C0028G0036 | Cyclic nucleotide-binding protein. | Glutamate dehydrogenase, glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.736 |
KRT65949.1 | guaB | XU11_C0016G0018 | XU11_C0035G0026 | Cyclic nucleotide-binding protein. | Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.592 |
KRT65949.1 | murD | XU11_C0016G0018 | XU11_C0002G0064 | Cyclic nucleotide-binding protein. | UDP-N-acetylmuramoylalanine--D-glutamate ligase, UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.512 |
KRT65993.1 | KRT63976.1 | XU11_C0015G0010 | XU11_C0059G0014 | Cell division protein FtsK/SpoIIIE, DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family. | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.686 |
KRT66065.1 | KRT63976.1 | XU11_C0014G0027 | XU11_C0059G0014 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.933 |
KRT66065.1 | apt | XU11_C0014G0027 | XU11_C0011G0058 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenine phosphoribosyltransferase, adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.760 |
KRT66065.1 | guaB | XU11_C0014G0027 | XU11_C0035G0026 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.814 |
KRT66065.1 | murD | XU11_C0014G0027 | XU11_C0002G0064 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase, UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.783 |
apt | KRT63976.1 | XU11_C0011G0058 | XU11_C0059G0014 | Adenine phosphoribosyltransferase, adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamate racemase, glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.624 |