STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT64465.1Nucleotide pyrophosphohydrolase, tetrapyrrole methylase family protein / MazG family protein. (389 aa)    
Predicted Functional Partners:
KRT64463.1
Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.893
KRT64466.1
PpiC-type peptidyl-prolyl cis-trans isomerase.
       0.794
KRT63062.1
Multi-sensor hybrid histidine kinase.
 
  
  0.780
KRT63063.1
Multi-sensor hybrid histidine kinase.
 
  
  0.777
rph
Ribonuclease PH, ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
       0.773
KRT63054.1
PAS domain-containing protein.
  
 
  0.744
KRT64267.1
Multi-sensor hybrid histidine kinase.
  
 
  0.725
KRT63190.1
Hypothetical protein.
    
  0.724
KRT64505.1
HAMP domain/GAF domain/GGDEF domain-containing protein.
    
  0.715
dcd
Deoxycytidine triphosphate deaminase, dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
     
 0.711
Your Current Organism:
Chloroflexi bacterium CSP14
NCBI taxonomy Id: 1640513
Other names: C. bacterium CSP1-4, Chloroflexi bacterium CSP1-4
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.