STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvDDihydroxy-acid dehydratase (DAD); Belongs to the IlvD/Edd family. (557 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.987
leuA
2-isopropylmalate synthase, Alpha-isopropylmalate synthase, Alpha-IPM synthetase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.967
ilvI
Acetolactate synthase large subunit (AHAS), Acetohydroxy-acid synthase large subunit, ALS.
 
 0.966
KRT70058.1
Aminodeoxychorismate lyase, branched-chain amino acid aminotransferase.
  
 0.960
ilvH
Acetolactate synthase small subunit (Acetohydroxy-acid synthase small subunit), AHAS, ALS.
 
 0.942
ilvE
Branched-chain-amino-acid aminotransferase (BCAT); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.938
KRT68586.1
Branched-chain amino acid aminotransferase, branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.938
leuC
3-isopropylmalate dehydratase large subunit 2 (Isopropylmalate isomerase 2); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.927
KRT70784.1
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
 
 0.916
KRT68658.1
GltB, glutamate synthase domain-containing 2, glutamate synthase (ferredoxin).
  
  
 0.908
Your Current Organism:
candidate division NC10 bacterium CSP15
NCBI taxonomy Id: 1640516
Other names: c. division NC10 bacterium CSP1-5, candidate division NC10 bacterium CSP1-5
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