node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAD | PUR3 | ING2E5A_2381 | ING2E5A_0687 | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | Phosphoribosylglycinamide formyltransferase, chloroplastic; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.482 |
CAD | gltB | ING2E5A_2381 | ING2E5A_2385 | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | Ferredoxin-dependent glutamate synthase 1; sp|P55037|GLTB_SYNY3;evalue=0.0; PctID=51.63; score=1462. | 0.770 |
CAD | purB | ING2E5A_2381 | ING2E5A_1897 | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | Adenylosuccinate lyase; sp|Q54J34|PUR8_DICDI;evalue=2e-142; PctID=58.77; score=506; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.699 |
CAD | purC | ING2E5A_2381 | ING2E5A_0593 | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | Phosphoribosylaminoimidazole-succinocarboxamide synthase {ECO:0000255|HAMAP-Rule:MF_00137}; sp|Q7MVR8|PUR7_PORGI;evalue=2e-129; PctID=70.51; score=462; Belongs to the SAICAR synthetase family. | 0.751 |
CAD | purD | ING2E5A_2381 | ING2E5A_0697 | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | Phosphoribosylamine-glycine ligase {ECO:0000255|HAMAP-Rule:MF_00138}; sp|Q8KBV8|PUR2_CHLTE;evalue=3e-097; PctID=45.43; score=355; Belongs to the GARS family. | 0.843 |
CAD | purF | ING2E5A_2381 | ING2E5A_0595 | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | Amidophosphoribosyltransferase{ECO:0000255|HAMA P-Rule:MF_01931}; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. purine/pyrimidine phosphoribosyltransferase family; sp|Q9L6B8|PUR1_PASMU;evalue=1e-008; PctID=37.17; score=62.0. | 0.941 |
CAD | purH | ING2E5A_2381 | ING2E5A_1497 | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | Bifunctional purine biosynthesis protein PurH {ECO:0000255|HAMAP-Rule:MF_00139}; sp|Q8A155|PUR9_BACTN;evalue=0.0; PctID=66.60; score=664. | 0.811 |
CAD | purL | ING2E5A_2381 | ING2E5A_2477 | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | Putative phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.973 |
CAD | purM | ING2E5A_2381 | ING2E5A_1686 | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | Phosphoribosylformylglycinamidine cyclo-ligase; sp|Q57656|PUR5_METJA;evalue=3e-012; PctID=34.07; score=73.2. | 0.861 |
CAD | pyr1-3 | ING2E5A_2381 | ING2E5A_1629 | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction. pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S)-dihydroorotate fr [...] | 0.909 |
PUR3 | CAD | ING2E5A_0687 | ING2E5A_2381 | Phosphoribosylglycinamide formyltransferase, chloroplastic; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | 0.482 |
PUR3 | purB | ING2E5A_0687 | ING2E5A_1897 | Phosphoribosylglycinamide formyltransferase, chloroplastic; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Adenylosuccinate lyase; sp|Q54J34|PUR8_DICDI;evalue=2e-142; PctID=58.77; score=506; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.865 |
PUR3 | purC | ING2E5A_0687 | ING2E5A_0593 | Phosphoribosylglycinamide formyltransferase, chloroplastic; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Phosphoribosylaminoimidazole-succinocarboxamide synthase {ECO:0000255|HAMAP-Rule:MF_00137}; sp|Q7MVR8|PUR7_PORGI;evalue=2e-129; PctID=70.51; score=462; Belongs to the SAICAR synthetase family. | 0.945 |
PUR3 | purD | ING2E5A_0687 | ING2E5A_0697 | Phosphoribosylglycinamide formyltransferase, chloroplastic; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Phosphoribosylamine-glycine ligase {ECO:0000255|HAMAP-Rule:MF_00138}; sp|Q8KBV8|PUR2_CHLTE;evalue=3e-097; PctID=45.43; score=355; Belongs to the GARS family. | 0.999 |
PUR3 | purF | ING2E5A_0687 | ING2E5A_0595 | Phosphoribosylglycinamide formyltransferase, chloroplastic; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Amidophosphoribosyltransferase{ECO:0000255|HAMA P-Rule:MF_01931}; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. purine/pyrimidine phosphoribosyltransferase family; sp|Q9L6B8|PUR1_PASMU;evalue=1e-008; PctID=37.17; score=62.0. | 0.945 |
PUR3 | purH | ING2E5A_0687 | ING2E5A_1497 | Phosphoribosylglycinamide formyltransferase, chloroplastic; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Bifunctional purine biosynthesis protein PurH {ECO:0000255|HAMAP-Rule:MF_00139}; sp|Q8A155|PUR9_BACTN;evalue=0.0; PctID=66.60; score=664. | 0.999 |
PUR3 | purL | ING2E5A_0687 | ING2E5A_2477 | Phosphoribosylglycinamide formyltransferase, chloroplastic; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Putative phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.998 |
PUR3 | purM | ING2E5A_0687 | ING2E5A_1686 | Phosphoribosylglycinamide formyltransferase, chloroplastic; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Phosphoribosylformylglycinamidine cyclo-ligase; sp|Q57656|PUR5_METJA;evalue=3e-012; PctID=34.07; score=73.2. | 0.952 |
gltB | CAD | ING2E5A_2385 | ING2E5A_2381 | Ferredoxin-dependent glutamate synthase 1; sp|P55037|GLTB_SYNY3;evalue=0.0; PctID=51.63; score=1462. | This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). ADP + phosphate + L-glutamate + carbamoyl phosphate. + N-carbamoyl-L-aspartate. aspartate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity); phosphorylation. 5-phosphoribose 1-diphosphate is an activator while UMP is an inhibitor of the CPSase reaction (By similarity). pathway; (S)-dihydroorotate from bicarbonate: step 1/3. pathway; (S)-dihydroorotate from bicarbonate: step 2/3. pathway; (S [...] | 0.770 |
gltB | purB | ING2E5A_2385 | ING2E5A_1897 | Ferredoxin-dependent glutamate synthase 1; sp|P55037|GLTB_SYNY3;evalue=0.0; PctID=51.63; score=1462. | Adenylosuccinate lyase; sp|Q54J34|PUR8_DICDI;evalue=2e-142; PctID=58.77; score=506; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.494 |