STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lplJ1Lipoate-protein ligase LplJ; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Is also able to use octanoate as substrate. (lipoyl)lysine + AMP. pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2. pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. minimal medium in the absence of supplements and have a wild-type pattern of lipoylated proteins. However, a double mutant strain lacking both lplJ and lipM is unable to grow in minimal medi [...] (257 aa)    
Predicted Functional Partners:
lipA
Lipoyl synthase {ECO:0000255|HAMAP-Rule:MF_00206}; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
 
 
 0.972
acoL
Dihydrolipoyl dehydrogenase; sp|O34324|DLDH3_BACSU;evalue=2e-078; PctID=35.60; score=293.
 
 0.949
acoB1
Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta; Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde; sp|O34591|ACOB_BACSU;evalue=2e-052; PctID=37.79; score=208.
  
 
 0.943
lipB
Octanoyltransferase {ECO:0000255|HAMAP-Rule:MF_00013}; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
   
 0.920
lplJ3
Lipoate-protein ligase LplJ; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Is also able to use octanoate as substrate. (lipoyl)lysine + AMP. pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2. pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. minimal medium in the absence of supplements and have a wild-type pattern of lipoylated proteins. However, a double mutant strain lacking both lplJ and lipM is unable to grow in minimal medi [...]
  
  
 
0.915
SCM57680.1
Acyl-acp thioesterase {ECO:0000313|EMBL:CEA15197,1}; tr|A0A098BZU9|A0A098BZU9_9PORP;evalue=6e-080; PctID=56.97; score=303.
     
  0.900
gcvH
Glycine cleavage system H protein {ECO:0000255|HAMAP-Rule:MF_00272}; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.886
pdhD1
Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. protein N(6)-(lipoyl)lysine + NADH. Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit; oxidoreductase family; sp|P11959|DLDH1_GEOSE;evalue=1e-075; PctID=38.50; score=284.
 
 
 0.854
acoB3
Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta; Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde; sp|O34591|ACOB_BACSU;evalue=2e-052; PctID=39.31; score=208.
  
 
 0.848
pdhC1
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence=; Note=Binds 1 lipoyl cofactor covalently; symmetry; sp|Q49110|ODP2_MYCCT;evalue=3e-037; PctID=29.76; score=156.
 
 0.834
Your Current Organism:
Petrimonas mucosa
NCBI taxonomy Id: 1642646
Other names: CECT 8611, DSM 28695, P. mucosa, Petrimonas mucosa Hahnke et al. 2016, Petrimonas sp. ING2-E5A, strain ING2 E5A, strain ING2-E5A
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