STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisA1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; sp|A5FFX7|HIS4_FLAJ1;evalue=2e-085; PctID=65.38; score=315. (239 aa)    
Predicted Functional Partners:
hisI
Histidine biosynthesis bifunctional protein HisIE {ECO:0000255|HAMAP-Rule:MF_01019}; sp|Q8A7Z7|HIS2_BACTN;evalue=9e-055; PctID=55.10; score=213; In the N-terminal section; belongs to the PRA-CH family.
 
 0.999
hisH
Imidazole glycerol phosphate synthase subunit HisH {ECO:0000255|HAMAP-Rule:MF_00278}; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 0.999
hisB
Histidine biosynthesis bifunctional protein HisB {ECO:0000255|HAMAP-Rule:MF_01022}; sp|Q7MLS4|HIS7_VIBVY;evalue=2e-101; PctID=51.52; score=369; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
  
 0.998
hisF
Imidazole glycerol phosphate synthase subunit HisF {ECO:0000255|HAMAP-Rule:MF_01013}; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
0.997
hisD
Histidinol dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01024}; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.990
hisG
ATP phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_00079}; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.989
hisC
Histidinol-phosphate aminotransferase {ECO:0000255|HAMAP-Rule:MF_01023}; sp|A5FFY0|HIS8_FLAJ1;evalue=9e-086; PctID=47.84; score=317; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.979
guaA
GMP synthase [glutamine-hydrolyzing] {ECO:0000255|HAMAP-Rule:MF_00344}; Catalyzes the synthesis of GMP from XMP.
  
  
 0.733
SCM57653.1
Putative protein BB_0007; sp|O51040|Y007_BORBU;evalue=2e-007; PctID=32.61; score=57.0.
  
  
 0.716
kdgK1
2-dehydro-3-deoxygluconokinase; Involved in the degradation of glucose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). dehydro-3-deoxy-6-phospho-D-gluconate. Kinetic parameters: KM=0.32 mM for KDG (at 35 degrees Celsius and pH 7.4); KM=3.6 mM for 2-keto-D-gluconate (at 35 degrees Celsius and pH 7.4); Note=Kcat is 11 (sec-1) for KDG and 2.2 (sec-1) for 2-keto-D-gluconate (at 35 degrees Celsius and pH 7.4); pH dependence: Optimum pH is between 6 and 9.; gluconate deg [...]
  
    0.547
Your Current Organism:
Petrimonas mucosa
NCBI taxonomy Id: 1642646
Other names: CECT 8611, DSM 28695, P. mucosa, Petrimonas mucosa Hahnke et al. 2016, Petrimonas sp. ING2-E5A, strain ING2 E5A, strain ING2-E5A
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