STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCM58514.1Transforms O-acetylhomoserine into homocysteine. methionine + acetate. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; sp|O13326|CYSD_SCHPO;evalue=4e-112; PctID=47.90; score=405. (428 aa)    
Predicted Functional Partners:
metA
Homoserine O-succinyltransferase {ECO:0000255|HAMAP-Rule:MF_00295}; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
 
 
 0.961
metH
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.937
patB
Cystathionine beta-lyase PatB; Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine. NH(3) + pyruvate. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Kinetic parameters: KM=1.62 mM for cystathionine; novo pathway; L-homocysteine from L-cystathionine: step 1/1. aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily; sp|Q08432|CBL_BACSU;evalue=3e-094; PctID=43.01; score=345.
   
 0.921
cysD1
Transforms O-acetylhomoserine into homocysteine. methionine + acetate. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; sp|P50125|CYSD_EMENI;evalue=8e-028; PctID=30.68; score=125.
  
  
 
0.916
ahcY
Adenosylhomocysteinase {ECO:0000255|HAMAP-Rule:MF_00563}; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
     
 0.910
thrA
Bifunctional aspartokinase/homoserine dehydrogenase; sp|P44505|AKH_HAEIN;evalue=1e-135; PctID=35.37; score=484.
 
 
 0.879
cysK
Cysteine synthase; sp|Q59447|CYSK_FLAS3;evalue=2e-089; PctID=61.07; score=329.
 
 
 0.845
cysD3
Transforms O-acetylhomoserine into homocysteine. methionine + acetate. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; sp|P50125|CYSD_EMENI;evalue=4e-143; PctID=57.85; score=508.
  
  
 
0.810
lrp
Leucine-responsive regulatory protein; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes; sp|P0A2S0|LRP_SALTY,sp|P0ACJ0|LRP_ECOLI, sp|P0ACJ1|LRP_ECOL6,sp|P0ACJ2|LRP_ECO57, sp|P0ACJ3|LRP_SHIFL,sp|P0ACJ4|LRP_ENTAE, sp|P37424|LRP_KLEPN,sp|P37425|LRP_SERMA;evalue=1e-022; PctID=37.06; score=105.
  
    0.537
sudA
Sulfide dehydrogenase subunit alpha {ECO:0000303|}; A bifunctional enzyme that catalyzes the reduction of elemental sulfur or polysulfide to hydrogen sulfide with NADPH as electron donor. Also functions as a reduced ferredoxin:NADP oxidoreductase with a very high affinity for reduced ferredoxin. Exhibits a broad specificity for various physiological and non-physiological substrates with varied reduction potentials such as methyl viologen, benzyl viologen, FAD, FMN, methylene blue, 2,6-dichlorophenolindophenol (DCIP), cytochrome C and ferricyanide with highest preference for benzyl viol [...]
  
  
 0.504
Your Current Organism:
Petrimonas mucosa
NCBI taxonomy Id: 1642646
Other names: CECT 8611, DSM 28695, P. mucosa, Petrimonas mucosa Hahnke et al. 2016, Petrimonas sp. ING2-E5A, strain ING2 E5A, strain ING2-E5A
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