STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCM59293.1[FeFe] hydrogenase maturase subunit HydE {ECO:0000305}; Required for the maturation of the [FeFe]-hydrogenase HydA (By similarity). Catalyzes the reductive cleavage of S-adenosyl-L-methionine (in vitro), suggesting it may contribute to the biosynthesis of an essential sulfur-containing ligand that binds to the hydrogenase active site [2Fe-2S] cluster. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine; Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence=; No [...] (368 aa)    
Predicted Functional Partners:
mnmE-2
tRNA modification GTPase MnmE {ECO:0000255|HAMAP-Rule:MF_00379}; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence=; Note=Binds 1 potassium ion per subunit; subunits. like GTPase superfamily. TrmE GTPase family. domain. Sequence=ABI60377.1; Type=Erroneous initiation; Evidence=; sp|Q0AE55|MNME_NITEC;evalue=4e-013; PctID=31.68; score=76.3.
   
 0.995
thiH
2-iminoacetate synthase; Catalyzes the radical-mediated cleavage of tyrosine to 2-iminoacetate and 4-cresol. 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+) + H(+). Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine; P30139:thiG; NbExp=2; IntAct=EBI-1125553, EBI-547059; yield glyoxylate and ammonium; sp|P30140|THIH_ECOLI;evalue=1e-043; PctID=28.68; score=177.
 
  
 0.961
birA
Bifunctional ligase/repressor BirA {ECO:0000255|HAMAP-Rule:MF_00978}; Acts both as a biotin-[acetyl-CoA-carboxylase] ligase and a repressor. ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]; sp|P0CI75|BIRA_BACSU;evalue=1e-019; PctID=35.85; score=97.1.
  
 
 0.929
hndD
NADP-reducing hydrogenase subunit HndC; Catalyzes the reduction of NADP in the presence of molecular H(2) to yield NADPH. Kinetic parameters: KM=0.09 mM for NADP (at 30 degrees Celsius and at pH 8); Vmax=0.013 umol/min/mg enzyme (at 30 degrees Celsius and at pH 8); pH dependence: Optimum pH is 8; subunits. HndD is probably the hydrogenase subunit; sp|Q46508|HNDD_DESFR;evalue=0.0; PctID=66.21; score=793.
 
  
 0.856
SCM59294.1
Putative protein {ECO:0000313|EMBL:EIY62019,1}; tr|I9HP94|I9HP94_9BACE,tr|R5J4J4|R5J4J4_9BACE; evalue=4e-011; PctID=55.07; score=73.2.
       0.773
SCM55685.1
8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein]. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; aminotransferase family. BioF subfamily; sp|A6LMP4|BIOF_THEM4;evalue=8e-083; PctID=42.26; score=307.
  
  
 0.668
kbl
2-amino-3-ketobutyrate coenzyme A ligase {ECO:0000255|HAMAP-Rule:MF_00985}; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
  
 0.668
SCM59290.1
Putative membrane protein STKORF319; sp|P96554|Y319_MYXXA;evalue=2e-028; PctID=36.45; score=126.
       0.538
UPS4
Ureide permease 4 {ECO:0000303|}; Proton-coupled transporter that transports a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds. protein Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9ZQ88-1; Name=2; IsoId=Q9ZQ88-2; Sequence=VSP_014325, VSP_014326; Note=No experimental confirmation available; Name=3; IsoId=Q9ZQ88-3; Sequence=VSP_014323, VSP_014324; Name=4; IsoId=Q9ZQ88-4; Sequence=VSP_014322, VSP_014323, VSP_014324; Note=No experimental confirmation available.; filaments and stigma, and the top and bottom parts of carpels in siliques. family. Sequence= [...]
  
    0.528
SCM56445.1
Sugar transport protein {ECO:0000313|EMBL:EEF88259,1}; tr|E2NIK0|E2NIK0_9BACE,tr|I9F5W9|I9F5W9_9BACE, tr|K9EE12|K9EE12_9BACE;evalue=2e-108; PctID=61.38; score=398.
  
    0.528
Your Current Organism:
Petrimonas mucosa
NCBI taxonomy Id: 1642646
Other names: CECT 8611, DSM 28695, P. mucosa, Petrimonas mucosa Hahnke et al. 2016, Petrimonas sp. ING2-E5A, strain ING2 E5A, strain ING2-E5A
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