STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
maeBNADP-dependent malic enzyme; sp|Q9ZFV8|MAO2_SALTY;evalue=0.0; PctID=47.50; score=649. (766 aa)    
Predicted Functional Partners:
nifJ
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin, which reduces nitrogenase. CoA + CO(2) + reduced flavodoxin. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 3 [4Fe-4S] clusters per subunit; sp|P03833|NIFJ_KLEPN;evalue=0.0; PctID=57.00; score=1316.
  
 0.976
fumA
Fumarate hydratase class I, aerobic {ECO:0000303|}; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
 
 
 0.975
korA
2-oxoglutarate oxidoreductase subunit KorA; Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha-ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitro; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M.tuberculosis during infection, flux through KOR l [...]
  
 
 0.959
pdhB1
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2). Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence=; Note=Binds 1 lipoyl cofactor covalently; Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58 [...]
  
 
 0.957
pdhB3
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2). Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; sp|P35488|ODPB_ACHLA;evalue=2e-097; PctID=53.89; score=356.
  
 
 0.957
pyk
Pyruvate kinase; sp|Q5HNK7|KPYK_STAEQ, sp|Q8CS69|KPYK_STAES;evalue=7e-077; PctID=40.29; score=288; Belongs to the pyruvate kinase family.
  
 0.957
pycB1
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. oxaloacetate. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; exceeded the ATP one, and by high concentration of ATP and alpha-ketoglutarate. pH dependence: Optimum pH is 8.5; Temperature dependence: Optimum temperature is 80-90 degrees Celsius.; Evidence=; sp|Q58628|PYCB_METJA;evalue=1e-031; PctID=38.28; score=138.
    
 0.956
pycB3
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. oxaloacetate. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; exceeded the ATP one, and by high concentration of ATP and alpha-ketoglutarate. pH dependence: Optimum pH is 8.5; Temperature dependence: Optimum temperature is 80-90 degrees Celsius.; Evidence=; sp|Q58628|PYCB_METJA;evalue=1e-028; PctID=32.58; score=128.
    
 0.956
mdh
Malate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00487}; Catalyzes the reversible oxidation of malate to oxaloacetate; sp|Q8ZVB2|MDH_PYRAE;evalue=6e-019; PctID=33.05; score=95.1; Belongs to the LDH/MDH superfamily.
  
 0.954
acoA
Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde. The alpha subunit is probably the catalytic subunit of the enzyme (By similarity). Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; regulated by AcoR and sigma-L factor. Subject to catabolite repression by glucose, in a CcpA-independent manner. utilize acetoin as carbon source; sp|O31404|ACOA_BACSU;evalue=1e-061; PctID=40.88; score=237.
  
 
 0.941
Your Current Organism:
Petrimonas mucosa
NCBI taxonomy Id: 1642646
Other names: CECT 8611, DSM 28695, P. mucosa, Petrimonas mucosa Hahnke et al. 2016, Petrimonas sp. ING2-E5A, strain ING2 E5A, strain ING2-E5A
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.