node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCM59371.1 | SCM59517.1 | ING2E5A_2575 | ING2E5A_2721 | Putative protein {ECO:0000313|EMBL:CEA15000,1}; tr|A0A098BWG1|A0A098BWG1_9PORP;evalue=1e-079; PctID=57.20; score=302. | Putative protein {ECO:0000313|EMBL:CEA15008,1}; tr|A0A098BXX4|A0A098BXX4_9PORP;evalue=2e-049; PctID=51.58; score=201. | 0.716 |
SCM59371.1 | ftsK | ING2E5A_2575 | ING2E5A_2720 | Putative protein {ECO:0000313|EMBL:CEA15000,1}; tr|A0A098BWG1|A0A098BWG1_9PORP;evalue=1e-079; PctID=57.20; score=302. | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | 0.709 |
SCM59371.1 | murA | ING2E5A_2575 | ING2E5A_1058 | Putative protein {ECO:0000313|EMBL:CEA15000,1}; tr|A0A098BWG1|A0A098BWG1_9PORP;evalue=1e-079; PctID=57.20; score=302. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase {ECO:0000255|HAMAP-Rule:MF_00111}; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.411 |
SCM59517.1 | SCM59371.1 | ING2E5A_2721 | ING2E5A_2575 | Putative protein {ECO:0000313|EMBL:CEA15008,1}; tr|A0A098BXX4|A0A098BXX4_9PORP;evalue=2e-049; PctID=51.58; score=201. | Putative protein {ECO:0000313|EMBL:CEA15000,1}; tr|A0A098BWG1|A0A098BWG1_9PORP;evalue=1e-079; PctID=57.20; score=302. | 0.716 |
SCM59517.1 | ftsK | ING2E5A_2721 | ING2E5A_2720 | Putative protein {ECO:0000313|EMBL:CEA15008,1}; tr|A0A098BXX4|A0A098BXX4_9PORP;evalue=2e-049; PctID=51.58; score=201. | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | 0.725 |
dnaA | ftsK | ING2E5A_0001 | ING2E5A_2720 | Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377}; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | 0.597 |
dnaA | mfd | ING2E5A_0001 | ING2E5A_2467 | Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377}; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Transcription-repair-coupling factor {ECO:0000255|HAMAP-Rule:MF_00969}; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.504 |
dnaA | noc | ING2E5A_0001 | ING2E5A_0741 | Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377}; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage. Rule:MF_02015}. Rule:MF_02015}; sp|A0RLQ9|NOC_BACAH,sp|B7JIK8|NOC_BACC0, sp|C1ER74|NOC_BACC3,sp|C3LGT8|NOC_BACAC, sp|C3P3F2|NOC_BACAA,sp|Q6HAF5|NOC_BACHK, sp|Q81JH5|NOC_BACAN;evalue=3e-044; PctID=45.45; score= [...] | 0.689 |
dnaA | soj | ING2E5A_0001 | ING2E5A_0740 | Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377}; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Inhibits the initiation of sporulation, Spo0J antagonizes this inhibition. Soj ultimately inhibits the activation (phosphorylation) of Spo0A. P05648:dnaA; NbExp=2; IntAct=EBI-2014674, EBI-2014722; chromosome partioning; sp|P37522|SOJ_BACSU;evalue=4e-069; PctID=53.09; score=261. | 0.587 |
ftsK | SCM59371.1 | ING2E5A_2720 | ING2E5A_2575 | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | Putative protein {ECO:0000313|EMBL:CEA15000,1}; tr|A0A098BWG1|A0A098BWG1_9PORP;evalue=1e-079; PctID=57.20; score=302. | 0.709 |
ftsK | SCM59517.1 | ING2E5A_2720 | ING2E5A_2721 | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | Putative protein {ECO:0000313|EMBL:CEA15008,1}; tr|A0A098BXX4|A0A098BXX4_9PORP;evalue=2e-049; PctID=51.58; score=201. | 0.725 |
ftsK | dnaA | ING2E5A_2720 | ING2E5A_0001 | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377}; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.597 |
ftsK | lrp | ING2E5A_2720 | ING2E5A_1844 | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | Leucine-responsive regulatory protein; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes; sp|P0A2S0|LRP_SALTY,sp|P0ACJ0|LRP_ECOLI, sp|P0ACJ1|LRP_ECOL6,sp|P0ACJ2|LRP_ECO57, sp|P0ACJ3|LRP_SHIFL,sp|P0ACJ4|LRP_ENTAE, sp|P37424|LRP_KLEPN,sp|P37425|LRP_SERMA;evalue=1e-022; PctID=37.06; score=105. | 0.591 |
ftsK | mfd | ING2E5A_2720 | ING2E5A_2467 | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | Transcription-repair-coupling factor {ECO:0000255|HAMAP-Rule:MF_00969}; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.680 |
ftsK | murA | ING2E5A_2720 | ING2E5A_1058 | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | UDP-N-acetylglucosamine 1-carboxyvinyltransferase {ECO:0000255|HAMAP-Rule:MF_00111}; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.584 |
ftsK | noc | ING2E5A_2720 | ING2E5A_0741 | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage. Rule:MF_02015}. Rule:MF_02015}; sp|A0RLQ9|NOC_BACAH,sp|B7JIK8|NOC_BACC0, sp|C1ER74|NOC_BACC3,sp|C3LGT8|NOC_BACAC, sp|C3P3F2|NOC_BACAA,sp|Q6HAF5|NOC_BACHK, sp|Q81JH5|NOC_BACAN;evalue=3e-044; PctID=45.45; score= [...] | 0.792 |
ftsK | soj | ING2E5A_2720 | ING2E5A_0740 | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | Inhibits the initiation of sporulation, Spo0J antagonizes this inhibition. Soj ultimately inhibits the activation (phosphorylation) of Spo0A. P05648:dnaA; NbExp=2; IntAct=EBI-2014674, EBI-2014722; chromosome partioning; sp|P37522|SOJ_BACSU;evalue=4e-069; PctID=53.09; score=261. | 0.598 |
ftsK | xerC | ING2E5A_2720 | ING2E5A_2427 | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | Tyrosine recombinase XerC {ECO:0000255|HAMAP-Rule:MF_01808}; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.617 |
ftsK | xerD | ING2E5A_2720 | ING2E5A_1228 | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | Tyrosine recombinase XerD {ECO:0000255|HAMAP-Rule:MF_01807}; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.584 |
lrp | ftsK | ING2E5A_1844 | ING2E5A_2720 | Leucine-responsive regulatory protein; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes; sp|P0A2S0|LRP_SALTY,sp|P0ACJ0|LRP_ECOLI, sp|P0ACJ1|LRP_ECOL6,sp|P0ACJ2|LRP_ECO57, sp|P0ACJ3|LRP_SHIFL,sp|P0ACJ4|LRP_ENTAE, sp|P37424|LRP_KLEPN,sp|P37425|LRP_SERMA;evalue=1e-022; PctID=37.06; score=105. | DNA translocase FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). similarity). membrane protein Note=Located at the septum. the localization to the septal ring and is requ [...] | 0.591 |