STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PSM36_1285RND family efflux transporter; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of th [...] (414 aa)    
Predicted Functional Partners:
PSM36_1287
ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; High confidence in function and specificity.
 
 
 0.922
yknY1
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis]; High confidence in function and specificity.
 
 0.879
PSM36_1664
ABC transporter permease; ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; High confidence in function and specificity.
 
 
 0.850
PSM36_2419
ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; High confidence in function and specificity.
 
 
 0.825
PSM36_2418
ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; High confidence in function and specificity.
 
 
 0.822
PSM36_1289
Outer membrane protein TolC; High confidence in function and specificity.
 
 
 0.769
PSM36_1663
ATP-binding cassette domain; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex c [...]
 
 0.764
PSM36_1284
RND family efflux transporter.
 
    
0.742
PSM36_1604
RND family efflux transporter; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of th [...]
  
     0.710
PSM36_2371
This family represents the periplasmic core domain found in a variety of ABC transporters. The structure of this family has been solved for the MacB protein. Some structural similarity was found to the periplasmic domain of the AcrB multidrug efflux transporter; High confidence in function and specificity.
 
 
 0.708
Your Current Organism:
Proteiniphilum saccharofermentans
NCBI taxonomy Id: 1642647
Other names: CECT 8610, DSM 28694, LMG 28299, LMG:28299, P. saccharofermentans, Proteiniphilum saccharofermentans Hahnke et al. 2016, Proteiniphilum sp. M3/6, strain M3/6
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