STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PSM36_2247Outer membrane protein TolC; High confidence in function and specificity. (439 aa)    
Predicted Functional Partners:
PSM36_2245
RND family efflux transporter; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of th [...]
 
 0.964
PSM36_2246
Multidrug efflux pump subunit AcrB; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer; High confidence in function and specificity; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 0.943
PSM36_2421
Outer membrane protein TolC; High confidence in function and specificity.
  
  
  0.937
PSM36_2350
Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Prot [...]
  
  
  0.930
PSM36_1605
Outer membrane efflux protein; The OEP family form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm; Conserved hypothetical protein.
  
  
  0.926
PSM36_1289
Outer membrane protein TolC; High confidence in function and specificity.
  
  
  0.917
PSM36_2132
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis]; High confidence in function and specificity.
  
  
 
0.911
PSM36_1661
Outer membrane protein TolC; High confidence in function and specificity.
  
  
 
0.909
PSM36_1016
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis]; High confidence in function and specificity.
     
 
0.900
PSM36_2492
Proteins in the outer membrane efflux protein family form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded beta-barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm; High confidence in function and specificity.
     
  0.900
Your Current Organism:
Proteiniphilum saccharofermentans
NCBI taxonomy Id: 1642647
Other names: CECT 8610, DSM 28694, LMG 28299, LMG:28299, P. saccharofermentans, Proteiniphilum saccharofermentans Hahnke et al. 2016, Proteiniphilum sp. M3/6, strain M3/6
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