H3G5E5_PHYRM protein (Phytophthora ramorum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

H3G5E5_PHYRM

Reverse transcriptase domain-containing protein. (119 aa)

Predicted Functional Partners:

H3G6N5_PHYRM

0.769

H3GB38_PHYRM

0.552

H3GB51_PHYRM

0.517

H3G9B1_PHYRM

0.494

H3G731_PHYRM

0.492

H3GB41_PHYRM

0.484

H3GAN2_PHYRM

0.437

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G5E5_PHYRM	H3G6N5_PHYRM	H3G5E5	H3G6N5	Reverse transcriptase domain-containing protein.	Uncharacterized protein.	0.769
H3G5E5_PHYRM	H3G731_PHYRM	H3G5E5	H3G731	Reverse transcriptase domain-containing protein.	Reverse transcriptase domain-containing protein.	0.492
H3G5E5_PHYRM	H3G9B1_PHYRM	H3G5E5	H3G9B1	Reverse transcriptase domain-containing protein.	RT_RNaseH_2 domain-containing protein.	0.494
H3G5E5_PHYRM	H3GAN2_PHYRM	H3G5E5	H3GAN2	Reverse transcriptase domain-containing protein.	RT_RNaseH_2 domain-containing protein.	0.437
H3G5E5_PHYRM	H3GB38_PHYRM	H3G5E5	H3GB38	Reverse transcriptase domain-containing protein.	RT_RNaseH_2 domain-containing protein.	0.552
H3G5E5_PHYRM	H3GB41_PHYRM	H3G5E5	H3GB41	Reverse transcriptase domain-containing protein.	RT_RNaseH_2 domain-containing protein.	0.484
H3G5E5_PHYRM	H3GB51_PHYRM	H3G5E5	H3GB51	Reverse transcriptase domain-containing protein.	RT_RNaseH_2 domain-containing protein.	0.517
H3G6N5_PHYRM	H3G5E5_PHYRM	H3G6N5	H3G5E5	Uncharacterized protein.	Reverse transcriptase domain-containing protein.	0.769
H3G6N5_PHYRM	H3G731_PHYRM	H3G6N5	H3G731	Uncharacterized protein.	Reverse transcriptase domain-containing protein.	0.769
H3G6N5_PHYRM	H3G9B1_PHYRM	H3G6N5	H3G9B1	Uncharacterized protein.	RT_RNaseH_2 domain-containing protein.	0.769
H3G6N5_PHYRM	H3GAN2_PHYRM	H3G6N5	H3GAN2	Uncharacterized protein.	RT_RNaseH_2 domain-containing protein.	0.769
H3G6N5_PHYRM	H3GB38_PHYRM	H3G6N5	H3GB38	Uncharacterized protein.	RT_RNaseH_2 domain-containing protein.	0.769
H3G6N5_PHYRM	H3GB41_PHYRM	H3G6N5	H3GB41	Uncharacterized protein.	RT_RNaseH_2 domain-containing protein.	0.769
H3G6N5_PHYRM	H3GB51_PHYRM	H3G6N5	H3GB51	Uncharacterized protein.	RT_RNaseH_2 domain-containing protein.	0.769
H3G731_PHYRM	H3G5E5_PHYRM	H3G731	H3G5E5	Reverse transcriptase domain-containing protein.	Reverse transcriptase domain-containing protein.	0.492
H3G731_PHYRM	H3G6N5_PHYRM	H3G731	H3G6N5	Reverse transcriptase domain-containing protein.	Uncharacterized protein.	0.769
H3G9B1_PHYRM	H3G5E5_PHYRM	H3G9B1	H3G5E5	RT_RNaseH_2 domain-containing protein.	Reverse transcriptase domain-containing protein.	0.494
H3G9B1_PHYRM	H3G6N5_PHYRM	H3G9B1	H3G6N5	RT_RNaseH_2 domain-containing protein.	Uncharacterized protein.	0.769
H3GAN2_PHYRM	H3G5E5_PHYRM	H3GAN2	H3G5E5	RT_RNaseH_2 domain-containing protein.	Reverse transcriptase domain-containing protein.	0.437
H3GAN2_PHYRM	H3G6N5_PHYRM	H3GAN2	H3G6N5	RT_RNaseH_2 domain-containing protein.	Uncharacterized protein.	0.769

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.788

expected number of edges:

15

PPI enrichment p-value:

7.77e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016575

Histone deacetylation

4 of 59

2.15

2.01

0.00012

GO:0016570

Histone modification

5 of 347

1.48

1.5

0.00016

GO:0045892

Negative regulation of transcription, DNA-templated

7 of 861

1.23

1.24

0.00012

GO:0042551

Neuron maturation

2 of 19

2.34

1.06

0.0111

GO:0051172

Negative regulation of nitrogen compound metabolic process

8 of 1667

1.0

0.96

0.00012

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000118

Histone deacetylase complex

6 of 77

2.21

4.23

1.09e-09

GO:1990391

DNA repair complex

2 of 36

2.06

0.92

0.0184

GO:0005654

Nucleoplasm

8 of 2131

0.89

0.78

0.00046

GO:0005634

Nucleus

11 of 6688

0.53

0.44

0.00057

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9604

HDACs deacetylate histones, and Sin3 complex

9 of 52

2.56

8.63

1.01e-18

CL:9654

NuRD complex, and Methyl-CpG binding protein 2/3, C-terminal domain

7 of 23

2.8

7.8

8.60e-16

CL:9606

HDACs deacetylate histones, and Sin3 complex

8 of 47

2.55

7.76

1.08e-16

CL:9687

Histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity, and HDACs deacetylate histones

5 of 5

3.32

6.46

1.59e-12

CL:9323

Chromatin organization, and Epigenetic regulation of gene expression

10 of 200

2.02

6.01

4.69e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214815

HDACs deacetylate histones

9 of 59

2.5

8.48

9.54e-19

MAP-4839726

Chromatin organization

9 of 303

1.79

4.13

6.52e-13

MAP-3247509

Chromatin modifying enzymes

9 of 303

1.79

4.13

6.52e-13

MAP-983231

Factors involved in megakaryocyte development and platelet production

7 of 217

1.83

3.48

1.05e-09

MAP-109582

Hemostasis

7 of 902

1.21

1.36

1.46e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000118

Histone deacetylase complex

3 of 74

1.93

1.2

0.0045

GOCC:1990391

DNA repair complex

2 of 33

2.1

0.76

0.0382

GOCC:0005634

Nucleus

9 of 3523

0.72

0.55

0.0031

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.3

0.0200

GOCC:0043227

Membrane-bounded organelle

10 of 7423

0.45

0.3

0.0382

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

7 of 1189

1.09

1.08

9.63e-05

KW-0156

Chromatin regulator

2 of 29

2.16

0.96

0.0162

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000949

ELM2 domain

3 of 15

2.62

1.81

0.00048

IPR017884

SANT domain

3 of 26

2.38

1.59

0.0011

IPR001005

SANT/Myb domain

3 of 46

2.13

1.29

0.0036

IPR009057

Homeobox-like domain superfamily

4 of 366

1.36

0.67

0.0361

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01189

The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex PUBMED:10226007. The domain is usually found to the N terminus of a myb-like DNA binding domain SANT ...

3 of 14

2.65

2.36

4.36e-05

SM00717

SANT SWI3, ADA2, N-CoR and TFIIIB DNA-binding domains

3 of 50

2.1

1.61

0.00074

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About