H3G7R5_PHYRM protein (Phytophthora ramorum) - STRING interaction network

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Predicted Interactions

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H3G7R5_PHYRM

Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (163 aa)

Predicted Functional Partners:

H3HDG9_PHYRM

0.988

H3GUK7_PHYRM

0.985

H3GBD4_PHYRM

0.983

H3GBR8_PHYRM

0.982

H3G9Z6_PHYRM

0.980

H3G9I3_PHYRM

0.942

H3G5V5_PHYRM

0.940

H3G7G6_PHYRM

0.856

H3GHT1_PHYRM

0.802

H3GAE9_PHYRM

0.801

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G5V5_PHYRM	H3G7R5_PHYRM	H3G5V5	H3G7R5	Uncharacterized protein.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.940
H3G5V5_PHYRM	H3G9Z6_PHYRM	H3G5V5	H3G9Z6	Uncharacterized protein.	Uncharacterized protein.	0.977
H3G5V5_PHYRM	H3GAE9_PHYRM	H3G5V5	H3GAE9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.712
H3G5V5_PHYRM	H3GBR8_PHYRM	H3G5V5	H3GBR8	Uncharacterized protein.	Uncharacterized protein.	0.907
H3G5V5_PHYRM	H3GHT1_PHYRM	H3G5V5	H3GHT1	Uncharacterized protein.	Uncharacterized protein.	0.490
H3G5V5_PHYRM	H3GUK7_PHYRM	H3G5V5	H3GUK7	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.988
H3G5V5_PHYRM	H3HDG9_PHYRM	H3G5V5	H3HDG9	Uncharacterized protein.	PPIase cyclophilin-type domain-containing protein.	0.992
H3G7G6_PHYRM	H3G7R5_PHYRM	H3G7G6	H3G7R5	PWI domain-containing protein.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.856
H3G7G6_PHYRM	H3G9I3_PHYRM	H3G7G6	H3G9I3	PWI domain-containing protein.	Slu7 domain-containing protein.	0.977
H3G7G6_PHYRM	H3G9Z6_PHYRM	H3G7G6	H3G9Z6	PWI domain-containing protein.	Uncharacterized protein.	0.849
H3G7G6_PHYRM	H3GAE9_PHYRM	H3G7G6	H3GAE9	PWI domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.742
H3G7G6_PHYRM	H3GBD4_PHYRM	H3G7G6	H3GBD4	PWI domain-containing protein.	Uncharacterized protein.	0.977
H3G7G6_PHYRM	H3GBR8_PHYRM	H3G7G6	H3GBR8	PWI domain-containing protein.	Uncharacterized protein.	0.971
H3G7G6_PHYRM	H3GHT1_PHYRM	H3G7G6	H3GHT1	PWI domain-containing protein.	Uncharacterized protein.	0.701
H3G7G6_PHYRM	H3GUK7_PHYRM	H3G7G6	H3GUK7	PWI domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.989
H3G7G6_PHYRM	H3HDG9_PHYRM	H3G7G6	H3HDG9	PWI domain-containing protein.	PPIase cyclophilin-type domain-containing protein.	0.991
H3G7R5_PHYRM	H3G5V5_PHYRM	H3G7R5	H3G5V5	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	Uncharacterized protein.	0.940
H3G7R5_PHYRM	H3G7G6_PHYRM	H3G7R5	H3G7G6	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	PWI domain-containing protein.	0.856
H3G7R5_PHYRM	H3G9I3_PHYRM	H3G7R5	H3G9I3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	Slu7 domain-containing protein.	0.942
H3G7R5_PHYRM	H3G9Z6_PHYRM	H3G7R5	H3G9Z6	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	Uncharacterized protein.	0.980

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Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000100

Regulation of establishment or maintenance of bipolar cell polarity regulating cell shape

7 of 11

2.32

5.13

1.84e-11

GO:0062200

RAM/MOR signaling pathway

6 of 6

2.52

5.08

9.76e-11

GO:0035556

Intracellular signal transduction

10 of 146

1.35

2.28

9.84e-11

GO:0072741

Protein localization to cell division site

3 of 4

2.39

2.13

9.71e-05

GO:0006468

Protein phosphorylation

7 of 85

1.43

2.03

3.37e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0106310

Protein serine kinase activity

7 of 66

1.54

2.26

3.04e-07

GO:0004674

Protein serine/threonine kinase activity

7 of 78

1.47

2.08

4.56e-07

GO:0005524

ATP binding

7 of 429

0.73

0.51

0.0091

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071958

New mitotic spindle pole body

3 of 6

2.22

1.8

0.00036

GO:0051286

Cell tip

6 of 122

1.21

1.16

0.00028

GO:0032153

Cell division site

7 of 184

1.1

1.04

0.00023

GO:0005816

Spindle pole body

5 of 102

1.21

1.02

0.0013

GO:0044732

Mitotic spindle pole body

4 of 81

1.21

0.82

0.0084

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:532

Mixed, incl. RAM/MOR signaling pathway, and Septation initiation signaling

9 of 20

2.17

6.26

1.26e-15

CL:557

RAM/MOR signaling pathway

6 of 6

2.52

5.23

4.70e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

4 of 80

1.22

0.8

0.0096

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-75153

Apoptotic execution phase

3 of 8

2.09

1.35

0.0026

MAP-109581

Apoptosis

3 of 15

1.82

1.11

0.0063

MAP-5357801

Programmed Cell Death

3 of 19

1.72

1.04

0.0079

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032153

Cell division site

6 of 96

1.31

1.33

0.00014

GOCC:0005816

Spindle pole body

4 of 46

1.46

1.05

0.0041

GOCC:0071958

New mitotic spindle pole body

2 of 5

2.12

0.81

0.0317

GOCC:0044732

Mitotic spindle pole body

3 of 34

1.46

0.72

0.0317

GOCC:0030427

Site of polarized growth

3 of 48

1.31

0.61

0.0474

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

3 of 31

1.5

0.78

0.0228

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000719

Protein kinase domain

7 of 73

1.5

2.08

8.32e-07

IPR011009

Protein kinase-like domain superfamily

7 of 84

1.44

1.95

1.05e-06

IPR000961

AGC-kinase, C-terminal

3 of 6

2.22

1.73

0.00049

IPR017441

Protein kinase, ATP binding site

5 of 52

1.5

1.52

0.00016

IPR008271

Serine/threonine-protein kinase, active site

5 of 61

1.43

1.4

0.00026

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00133

Extension to Ser/Thr-type protein kinases

4 of 7

2.28

2.93

1.66e-06

SM00220

Serine/Threonine protein kinases, catalytic domain

6 of 50

1.6

2.24

9.83e-07

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