STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H3G7Y5_PHYRMDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (628 aa)    
Predicted Functional Partners:
H3G6N5_PHYRM
Uncharacterized protein.
   
 0.998
H3GCB9_PHYRM
Replication protein A subunit.
    
 0.978
H3GG34_PHYRM
Uncharacterized protein.
    
 0.965
H3GZE2_PHYRM
ERCC4 domain-containing protein.
    
 0.937
H3G560_PHYRM
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.912
H3GQI3_PHYRM
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.912
H3GV41_PHYRM
Uncharacterized protein.
  
 0.912
H3H5C6_PHYRM
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.912
H3HDP3_PHYRM
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.912
H3GFY1_PHYRM
Uridine kinase; Belongs to the uridine kinase family.
    
   0.907
Your Current Organism:
Phytophthora ramorum
NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death
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