node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | H3G5W3_PHYRM | H3GAS1 | H3G5W3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | 0.980 |
FEN1 | H3G6F5_PHYRM | H3GAS1 | H3G6F5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.697 |
FEN1 | H3GA74_PHYRM | H3GAS1 | H3GA74 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | AAA_23 domain-containing protein. | 0.908 |
FEN1 | H3GFX6_PHYRM | H3GAS1 | H3GFX6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.665 |
FEN1 | H3GM95_PHYRM | H3GAS1 | H3GM95 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.732 |
FEN1 | H3GMG2_PHYRM | H3GAS1 | H3GMG2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.697 |
FEN1 | H3GXW6_PHYRM | H3GAS1 | H3GXW6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.908 |
FEN1 | H3HC67_PHYRM | H3GAS1 | H3HC67 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.732 |
FEN1 | H3HDB4_PHYRM | H3GAS1 | H3HDB4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | FHA domain-containing protein. | 0.818 |
FEN1 | H3HDP1_PHYRM | H3GAS1 | H3HDP1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.899 |
H3G5W3_PHYRM | FEN1 | H3G5W3 | H3GAS1 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.980 |
H3G5W3_PHYRM | H3G6F5_PHYRM | H3G5W3 | H3G6F5 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.971 |
H3G5W3_PHYRM | H3GA74_PHYRM | H3G5W3 | H3GA74 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | AAA_23 domain-containing protein. | 0.995 |
H3G5W3_PHYRM | H3GFX6_PHYRM | H3G5W3 | H3GFX6 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.981 |
H3G5W3_PHYRM | H3GM95_PHYRM | H3G5W3 | H3GM95 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.925 |
H3G5W3_PHYRM | H3GMG2_PHYRM | H3G5W3 | H3GMG2 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.971 |
H3G5W3_PHYRM | H3GXW6_PHYRM | H3G5W3 | H3GXW6 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.997 |
H3G5W3_PHYRM | H3HC67_PHYRM | H3G5W3 | H3HC67 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.925 |
H3G5W3_PHYRM | H3HDB4_PHYRM | H3G5W3 | H3HDB4 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | FHA domain-containing protein. | 0.999 |
H3G5W3_PHYRM | H3HDP1_PHYRM | H3G5W3 | H3HDP1 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.832 |