H3GC79_PHYRM protein (Phytophthora ramorum) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

H3GC79_PHYRM

Uncharacterized protein. (2929 aa)

Predicted Functional Partners:

H3HC84_PHYRM

0.727

H3GDL5_PHYRM

0.705

H3GC30_PHYRM

0.635

H3H3K4_PHYRM

0.625

H3GXH4_PHYRM

0.618

H3GHQ0_PHYRM

0.614

H3HBI0_PHYRM

0.602

H3GIQ5_PHYRM

0.585

H3GQ86_PHYRM

0.585

H3G9M5_PHYRM

0.568

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G9M5_PHYRM	H3GC30_PHYRM	H3G9M5	H3GC30	N-acetyltransferase domain-containing protein.	TFIID_20kDa domain-containing protein.	0.962
H3G9M5_PHYRM	H3GC79_PHYRM	H3G9M5	H3GC79	N-acetyltransferase domain-containing protein.	Uncharacterized protein.	0.568
H3G9M5_PHYRM	H3GIQ5_PHYRM	H3G9M5	H3GIQ5	N-acetyltransferase domain-containing protein.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.915
H3G9M5_PHYRM	H3GQ86_PHYRM	H3G9M5	H3GQ86	N-acetyltransferase domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.915
H3G9M5_PHYRM	H3GXH4_PHYRM	H3G9M5	H3GXH4	N-acetyltransferase domain-containing protein.	TAF domain-containing protein.	0.960
H3G9M5_PHYRM	H3HBI0_PHYRM	H3G9M5	H3HBI0	N-acetyltransferase domain-containing protein.	Uncharacterized protein.	0.976
H3G9M5_PHYRM	H3HC84_PHYRM	H3G9M5	H3HC84	N-acetyltransferase domain-containing protein.	Uncharacterized protein.	0.963
H3GC30_PHYRM	H3G9M5_PHYRM	H3GC30	H3G9M5	TFIID_20kDa domain-containing protein.	N-acetyltransferase domain-containing protein.	0.962
H3GC30_PHYRM	H3GC79_PHYRM	H3GC30	H3GC79	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.635
H3GC30_PHYRM	H3GIQ5_PHYRM	H3GC30	H3GIQ5	TFIID_20kDa domain-containing protein.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.943
H3GC30_PHYRM	H3GQ86_PHYRM	H3GC30	H3GQ86	TFIID_20kDa domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.943
H3GC30_PHYRM	H3GXH4_PHYRM	H3GC30	H3GXH4	TFIID_20kDa domain-containing protein.	TAF domain-containing protein.	0.999
H3GC30_PHYRM	H3HBI0_PHYRM	H3GC30	H3HBI0	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.999
H3GC30_PHYRM	H3HC84_PHYRM	H3GC30	H3HC84	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.991
H3GC79_PHYRM	H3G9M5_PHYRM	H3GC79	H3G9M5	Uncharacterized protein.	N-acetyltransferase domain-containing protein.	0.568
H3GC79_PHYRM	H3GC30_PHYRM	H3GC79	H3GC30	Uncharacterized protein.	TFIID_20kDa domain-containing protein.	0.635
H3GC79_PHYRM	H3GDL5_PHYRM	H3GC79	H3GDL5	Uncharacterized protein.	Uncharacterized protein.	0.705
H3GC79_PHYRM	H3GHQ0_PHYRM	H3GC79	H3GHQ0	Uncharacterized protein.	SH3 domain-containing protein.	0.614
H3GC79_PHYRM	H3GIQ5_PHYRM	H3GC79	H3GIQ5	Uncharacterized protein.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.585
H3GC79_PHYRM	H3GQ86_PHYRM	H3GC79	H3GQ86	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.585

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.849

expected number of edges:

11

PPI enrichment p-value:

1.04e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

11 of 41

1.98

6.18

1.06e-18

GO:0000160

Phosphorelay signal transduction system

10 of 34

2.02

6.02

4.17e-17

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

8 of 13

2.34

6.34

1.92e-14

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 133

1.38

2.28

4.31e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 760

0.62

0.48

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2926

Two-component regulatory system, and Histidine kinase domain

10 of 23

2.18

7.21

1.41e-18

CL:2928

Two-component regulatory system, and Histidine kinase domain

9 of 18

2.25

6.93

6.92e-17

CL:2931

Two-component regulatory system, and PAS domain

8 of 12

2.37

6.82

1.80e-15

CL:2923

Phosphorelay signal transduction system, and P-type ion transporter activity

11 of 35

2.04

6.74

1.59e-19

CL:2933

Histidine kinase domain, and Transcriptional regulatory protein, C terminal

3 of 5

2.32

2.12

9.31e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aka02020

Two-component system

4 of 79

1.25

0.87

0.0063

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 67

1.67

3.58

2.78e-12

KW-0902

Two-component regulatory system

4 of 14

2.0

2.46

7.00e-06

KW-0067

ATP-binding

6 of 232

0.96

0.81

0.00089

KW-0597

Phosphoprotein

2 of 22

1.51

0.67

0.0435

KW-1133

Transmembrane helix

8 of 684

0.61

0.47

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

9 of 11

2.46

7.81

2.22e-17

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

9 of 12

2.42

7.7

2.22e-17

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 12

2.42

7.7

2.22e-17

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

8 of 11

2.41

6.82

3.22e-15

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 11

2.41

6.82

3.22e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

9 of 11

2.46

8.28

1.41e-18

SM00388

His Kinase A (phosphoacceptor) domain

8 of 11

2.41

7.18

4.08e-16

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

4 of 4

2.55

3.75

6.79e-08

SM00091

PAS domain

2 of 3

2.37

1.52

0.0015

SM00862

Transcriptional regulatory protein, C terminal

2 of 12

1.77

0.99

0.0109

(more ...)

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