H3GCC5_PHYRM protein (Phytophthora ramorum) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

H3GCC5_PHYRM

RING-type domain-containing protein. (264 aa)

Predicted Functional Partners:

H3G8T9_PHYRM

0.663

H3G789_PHYRM

0.641

H3G8V5_PHYRM

0.641

H3G8Z6_PHYRM

0.572

H3GGI9_PHYRM

0.537

H3GYJ5_PHYRM

0.504

H3HC07_PHYRM

0.504

H3G543_PHYRM

0.420

H3G5H7_PHYRM

0.420

H3G682_PHYRM

0.420

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G543_PHYRM	H3G789_PHYRM	H3G543	H3G789	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.868
H3G543_PHYRM	H3G8T9_PHYRM	H3G543	H3G8T9	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.873
H3G543_PHYRM	H3G8V5_PHYRM	H3G543	H3G8V5	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.868
H3G543_PHYRM	H3G8Z6_PHYRM	H3G543	H3G8Z6	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.863
H3G543_PHYRM	H3GCC5_PHYRM	H3G543	H3GCC5	Ubiquitin-like domain-containing protein.	RING-type domain-containing protein.	0.420
H3G543_PHYRM	H3GGI9_PHYRM	H3G543	H3GGI9	Ubiquitin-like domain-containing protein.	TPR_REGION domain-containing protein.	0.544
H3G543_PHYRM	H3GYJ5_PHYRM	H3G543	H3GYJ5	Ubiquitin-like domain-containing protein.	HECT domain-containing protein.	0.942
H3G543_PHYRM	H3HC07_PHYRM	H3G543	H3HC07	Ubiquitin-like domain-containing protein.	HECT domain-containing protein.	0.942
H3G5H7_PHYRM	H3G789_PHYRM	H3G5H7	H3G789	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.868
H3G5H7_PHYRM	H3G8T9_PHYRM	H3G5H7	H3G8T9	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.880
H3G5H7_PHYRM	H3G8V5_PHYRM	H3G5H7	H3G8V5	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.877
H3G5H7_PHYRM	H3G8Z6_PHYRM	H3G5H7	H3G8Z6	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.863
H3G5H7_PHYRM	H3GCC5_PHYRM	H3G5H7	H3GCC5	Uncharacterized protein.	RING-type domain-containing protein.	0.420
H3G5H7_PHYRM	H3GGI9_PHYRM	H3G5H7	H3GGI9	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.544
H3G5H7_PHYRM	H3GYJ5_PHYRM	H3G5H7	H3GYJ5	Uncharacterized protein.	HECT domain-containing protein.	0.942
H3G5H7_PHYRM	H3HC07_PHYRM	H3G5H7	H3HC07	Uncharacterized protein.	HECT domain-containing protein.	0.942
H3G682_PHYRM	H3G789_PHYRM	H3G682	H3G789	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.868
H3G682_PHYRM	H3G8T9_PHYRM	H3G682	H3G8T9	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.877
H3G682_PHYRM	H3G8V5_PHYRM	H3G682	H3G8V5	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.874
H3G682_PHYRM	H3G8Z6_PHYRM	H3G682	H3G8Z6	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.863

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

15

PPI enrichment p-value:

4.11e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019646

Aerobic electron transport chain

4 of 4

2.62

3.77

2.04e-07

GO:0009060

Aerobic respiration

5 of 23

1.96

3.07

3.22e-07

GO:0006091

Generation of precursor metabolites and energy

8 of 88

1.58

2.85

1.38e-09

GO:0044237

Cellular metabolic process

9 of 1360

0.44

0.33

0.0064

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

7 of 14

2.32

5.86

1.28e-12

GO:0004129

Cytochrome-c oxidase activity

6 of 11

2.36

5.16

8.49e-11

GO:0009055

Electron transfer activity

7 of 43

1.83

3.76

2.70e-10

GO:0016491

Oxidoreductase activity

8 of 351

0.98

1.06

2.63e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

2 of 4

2.32

1.56

0.0018

GO:0005886

Plasma membrane

7 of 409

0.85

0.72

0.00068

GO:0016021

Integral component of membrane

8 of 752

0.65

0.51

0.0012

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1764

Cytochrome-c oxidase activity, and Cytochrome c, class IC

5 of 10

2.32

4.13

1.28e-08

CL:1766

Cytochrome-c oxidase activity

4 of 5

2.52

3.69

2.31e-07

CL:1758

Electron transfer activity, and Heme metabolic process

6 of 28

1.95

3.56

1.21e-08

CL:1756

Mixed, incl. Electron transfer activity, and Hemerythrin-like

7 of 69

1.63

2.8

1.21e-08

CL:1755

Mixed, incl. Electron transfer activity, and Peptidase M16, N-terminal

8 of 105

1.5

2.55

3.90e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mtt00190

Oxidative phosphorylation

5 of 27

1.89

2.91

4.33e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

6 of 27

1.97

3.68

6.91e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

2 of 4

2.32

1.22

0.0076

KW-0249

Electron transport

2 of 4

2.32

1.22

0.0076

KW-0560

Oxidoreductase

5 of 145

1.16

0.95

0.0021

KW-1133

Transmembrane helix

7 of 817

0.55

0.36

0.0280

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00510

Cytochrome c oxidase subunit III

3 of 3

2.62

2.3

0.00010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035973

Cytochrome c oxidase subunit III-like superfamily

4 of 4

2.62

3.32

1.41e-06

IPR024791

Cytochrome c oxidase subunit III

4 of 4

2.62

3.32

1.41e-06

IPR013833

Cytochrome c oxidase, subunit III, 4-helical bundle

4 of 4

2.62

3.32

1.41e-06

IPR000298

Cytochrome c oxidase subunit III-like

4 of 4

2.62

3.32

1.41e-06

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