H3GF65_PHYRM protein (Phytophthora ramorum) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

H3GF65_PHYRM

Reverse transcriptase domain-containing protein. (942 aa)

Predicted Functional Partners:

H3G6N5_PHYRM

0.769

H3HAB1_PHYRM

0.476

H3H0K0_PHYRM

0.412

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G6N5_PHYRM	H3GF65_PHYRM	H3G6N5	H3GF65	Uncharacterized protein.	Reverse transcriptase domain-containing protein.	0.769
H3G6N5_PHYRM	H3H0K0_PHYRM	H3G6N5	H3H0K0	Uncharacterized protein.	Uncharacterized protein.	0.769
H3G6N5_PHYRM	H3HAB1_PHYRM	H3G6N5	H3HAB1	Uncharacterized protein.	RT_RNaseH_2 domain-containing protein.	0.769
H3GF65_PHYRM	H3G6N5_PHYRM	H3GF65	H3G6N5	Reverse transcriptase domain-containing protein.	Uncharacterized protein.	0.769
H3GF65_PHYRM	H3H0K0_PHYRM	H3GF65	H3H0K0	Reverse transcriptase domain-containing protein.	Uncharacterized protein.	0.412
H3GF65_PHYRM	H3HAB1_PHYRM	H3GF65	H3HAB1	Reverse transcriptase domain-containing protein.	RT_RNaseH_2 domain-containing protein.	0.476
H3H0K0_PHYRM	H3G6N5_PHYRM	H3H0K0	H3G6N5	Uncharacterized protein.	Uncharacterized protein.	0.769
H3H0K0_PHYRM	H3GF65_PHYRM	H3H0K0	H3GF65	Uncharacterized protein.	Reverse transcriptase domain-containing protein.	0.412
H3HAB1_PHYRM	H3G6N5_PHYRM	H3HAB1	H3G6N5	RT_RNaseH_2 domain-containing protein.	Uncharacterized protein.	0.769
H3HAB1_PHYRM	H3GF65_PHYRM	H3HAB1	H3GF65	RT_RNaseH_2 domain-containing protein.	Reverse transcriptase domain-containing protein.	0.476

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.891

expected number of edges:

10

PPI enrichment p-value:

1.19e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

11 of 94

2.25

8.28

3.36e-21

GO:0042761

Very long-chain fatty acid biosynthetic process

7 of 14

2.88

7.93

7.09e-16

GO:0030497

Fatty acid elongation

7 of 14

2.88

7.93

7.09e-16

GO:0006636

Unsaturated fatty acid biosynthetic process

6 of 34

2.43

5.19

3.19e-11

GO:0034626

Fatty acid elongation, polyunsaturated fatty acid

4 of 8

2.88

4.19

1.71e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009922

Fatty acid elongase activity

4 of 8

2.88

3.72

1.36e-07

GO:0102756

Very-long-chain 3-ketoacyl-CoA synthase activity

3 of 7

2.81

2.53

2.29e-05

GO:0016717

Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

3 of 11

2.61

2.31

5.21e-05

GO:0102345

3-hydroxy-lignoceroyl-CoA dehydratase activity

2 of 4

2.88

1.46

0.0023

GO:0102344

3-hydroxy-behenoyl-CoA dehydratase activity

2 of 4

2.88

1.46

0.0023

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030176

Integral component of endoplasmic reticulum membrane

5 of 104

1.86

2.64

9.36e-07

GO:0005789

Endoplasmic reticulum membrane

11 of 714

1.37

2.48

1.33e-12

GO:0016021

Integral component of membrane

11 of 4304

0.59

0.52

4.72e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9984

Fatty acid elongation, and Fatty acid desaturase

11 of 24

2.84

13.2

2.30e-27

CL:9987

Biosynthesis of unsaturated fatty acids

10 of 17

2.95

12.5

3.86e-25

CL:9989

Fatty acid metabolism

6 of 11

2.92

6.77

1.80e-13

CL:9991

Protein-tyrosine phosphatase-like, PTPLA, and 3-oxo-5-alpha-steroid 4-dehydrogenase

3 of 5

2.96

2.77

8.90e-06

CL:10001

Fatty acid desaturase type 1, conserved site, and ELO family, conserved site

3 of 5

2.96

2.77

8.90e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla01040

Biosynthesis of unsaturated fatty acids

11 of 28

2.77

13.27

4.15e-28

apla01212

Fatty acid metabolism

11 of 47

2.55

11.53

2.82e-26

apla00062

Fatty acid elongation

8 of 20

2.78

9.48

1.96e-19

apla01100

Metabolic pathways

11 of 996

1.22

1.98

1.59e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-75876

Synthesis of very long-chain fatty acyl-CoAs

8 of 26

2.67

8.37

1.72e-17

MAP-75105

Fatty acyl-CoA biosynthesis

8 of 43

2.45

7.28

4.02e-16

MAP-8978868

Fatty acid metabolism

11 of 183

1.96

6.12

6.85e-19

MAP-2046105

Linoleic acid (LA) metabolism

5 of 10

2.88

5.53

4.37e-11

MAP-2046106

Alpha-linolenic acid (ALA) metabolism

5 of 19

2.6

4.82

5.14e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

6 of 16

2.75

6.47

3.69e-13

KW-0256

Endoplasmic reticulum

5 of 78

1.99

3.2

7.80e-08

KW-0456

Lyase

2 of 49

1.79

0.9

0.0174

KW-1133

Transmembrane helix

11 of 3820

0.64

0.59

5.04e-06

KW-0808

Transferase

4 of 694

0.94

0.56

0.0253

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01151

GNS1/SUR4 family

4 of 8

2.88

3.79

9.96e-08

PF00487

Fatty acid desaturase

3 of 10

2.66

2.29

5.97e-05

PF04387

Protein tyrosine phosphatase-like protein, PTPLA

2 of 4

2.88

1.33

0.0039

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002076

ELO family

4 of 8

2.88

3.53

3.11e-07

IPR030457

ELO family, conserved site

3 of 6

2.88

2.34

5.48e-05

IPR012171

Fatty acid desaturase

3 of 6

2.88

2.34

5.48e-05

IPR005804

Fatty acid desaturase domain

3 of 10

2.66

2.19

9.32e-05

IPR001199

Cytochrome b5-like heme/steroid binding domain

3 of 12

2.58

2.12

0.00012

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 12

2.58

2.23

7.11e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

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