H3GME3_PHYRM protein (Phytophthora ramorum) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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H3GME3_PHYRM

Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (840 aa)

Predicted Functional Partners:

H3GWU2_PHYRM

0.899

H3G803_PHYRM

0.715

H3G595_PHYRM

0.710

H3G8Q0_PHYRM

0.709

H3G588_PHYRM

0.707

H3H478_PHYRM

0.703

H3HDV1_PHYRM

0.703

H3G7K4_PHYRM

0.656

H3HE00_PHYRM

0.656

H3GA28_PHYRM

0.611

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G588_PHYRM	H3G595_PHYRM	H3G588	H3G595	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.769
H3G588_PHYRM	H3G7K4_PHYRM	H3G588	H3G7K4	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.851
H3G588_PHYRM	H3G803_PHYRM	H3G588	H3G803	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.812
H3G588_PHYRM	H3GA28_PHYRM	H3G588	H3GA28	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	WD_REPEATS_REGION domain-containing protein.	0.505
H3G588_PHYRM	H3GME3_PHYRM	H3G588	H3GME3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.707
H3G588_PHYRM	H3GWU2_PHYRM	H3G588	H3GWU2	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.814
H3G588_PHYRM	H3H478_PHYRM	H3G588	H3H478	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.840
H3G588_PHYRM	H3HDV1_PHYRM	H3G588	H3HDV1	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.840
H3G588_PHYRM	H3HE00_PHYRM	H3G588	H3HE00	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.843
H3G595_PHYRM	H3G588_PHYRM	H3G595	H3G588	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.769
H3G595_PHYRM	H3G7K4_PHYRM	H3G595	H3G7K4	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.772
H3G595_PHYRM	H3G803_PHYRM	H3G595	H3G803	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.836
H3G595_PHYRM	H3GME3_PHYRM	H3G595	H3GME3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.710
H3G595_PHYRM	H3GWU2_PHYRM	H3G595	H3GWU2	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.795
H3G595_PHYRM	H3H478_PHYRM	H3G595	H3H478	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.815
H3G595_PHYRM	H3HDV1_PHYRM	H3G595	H3HDV1	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.816
H3G595_PHYRM	H3HE00_PHYRM	H3G595	H3HE00	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.762
H3G7K4_PHYRM	H3G588_PHYRM	H3G7K4	H3G588	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.851
H3G7K4_PHYRM	H3G595_PHYRM	H3G7K4	H3G595	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.772
H3G7K4_PHYRM	H3G803_PHYRM	H3G7K4	H3G803	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.840

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Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.723

expected number of edges:

12

PPI enrichment p-value:

4.03e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007005

Mitochondrion organization

7 of 182

1.51

2.06

1.39e-06

GO:0006626

Protein targeting to mitochondrion

4 of 41

1.92

1.74

0.00027

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 7

2.38

1.08

0.0101

GO:0015031

Protein transport

6 of 381

1.12

0.96

0.0011

GO:0033617

Mitochondrial cytochrome c oxidase assembly

2 of 19

1.95

0.74

0.0408

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015035

Protein-disulfide reductase activity

3 of 17

2.17

1.41

0.0021

GO:0140318

Protein transporter activity

3 of 22

2.06

1.39

0.0021

GO:0016972

Thiol oxidase activity

2 of 3

2.75

1.28

0.0048

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005758

Mitochondrial intermembrane space

6 of 41

2.09

3.82

4.29e-09

GO:0005740

Mitochondrial envelope

9 of 329

1.36

2.14

4.29e-09

GO:0005743

Mitochondrial inner membrane

7 of 226

1.42

2.03

2.05e-07

GO:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 2

2.93

1.78

0.00058

GO:0005739

Mitochondrion

10 of 874

0.99

1.16

8.02e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13036

Protein targeting to mitochondrion, and Tim10-like

8 of 29

2.37

6.85

1.51e-15

CL:13032

Mixed, incl. Protein localization to mitochondrion, and Respiratory chain complex IV assembly

10 of 70

2.08

6.4

2.23e-17

CL:13083

Protein import into mitochondrial intermembrane space, and Tim10-like

4 of 5

2.83

4.04

3.17e-08

CL:13038

TIM23 mitochondrial import inner membrane translocase complex, and TIM22 mitochondrial import inner membrane insertion complex

3 of 14

2.26

1.97

0.00017

CL:13054

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

2 of 6

2.45

1.21

0.0059

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

9 of 50

2.18

6.44

4.37e-16

MAP-9609507

Protein localization

9 of 239

1.5

2.73

1.41e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005758

Mitochondrial intermembrane space

8 of 48

2.15

5.5

1.62e-13

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

4 of 4

2.93

4.23

1.58e-08

GOCC:0005740

Mitochondrial envelope

9 of 310

1.39

2.28

9.81e-10

GOCC:0098798

Mitochondrial protein complex

5 of 168

1.4

1.5

7.20e-05

GOCC:0043231

Intracellular membrane-bounded organelle

11 of 2850

0.51

0.44

0.00017

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

6 of 29

2.24

4.58

1.98e-10

KW-0811

Translocation

4 of 9

2.58

3.7

9.09e-08

KW-0496

Mitochondrion

4 of 108

1.5

1.41

0.00037

KW-0143

Chaperone

2 of 22

1.89

0.96

0.0140

KW-0862

Zinc

4 of 343

0.99

0.62

0.0176

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02953

Tim10/DDP family zinc finger

4 of 4

2.93

3.88

7.12e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035427

Tim10-like domain superfamily

4 of 4

2.93

3.64

2.03e-07

IPR004217

Tim10-like

4 of 4

2.93

3.64

2.03e-07

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