node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
H3G8D7_PHYRM | H3G967_PHYRM | H3G8D7 | H3G967 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.884 |
H3G8D7_PHYRM | H3G9E0_PHYRM | H3G8D7 | H3G9E0 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.896 |
H3G8D7_PHYRM | H3GD15_PHYRM | H3G8D7 | H3GD15 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.867 |
H3G8D7_PHYRM | H3GN18_PHYRM | H3G8D7 | H3GN18 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.884 |
H3G8D7_PHYRM | H3GPN9_PHYRM | H3G8D7 | H3GPN9 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Uncharacterized protein. | 0.884 |
H3G8D7_PHYRM | H3GWN7_PHYRM | H3G8D7 | H3GWN7 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.935 |
H3G8D7_PHYRM | H3H1A3_PHYRM | H3G8D7 | H3H1A3 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | tRNA-binding domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.867 |
H3G8D7_PHYRM | H3H3C1_PHYRM | H3G8D7 | H3H3C1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | ATP-grasp domain-containing protein. | 0.891 |
H3G8D7_PHYRM | H3HC90_PHYRM | H3G8D7 | H3HC90 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | FSH1 domain-containing protein. | 0.565 |
H3G967_PHYRM | H3G8D7_PHYRM | H3G967 | H3G8D7 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.884 |
H3G967_PHYRM | H3G9E0_PHYRM | H3G967 | H3G9E0 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.997 |
H3G967_PHYRM | H3GN18_PHYRM | H3G967 | H3GN18 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.903 |
H3G967_PHYRM | H3GPN9_PHYRM | H3G967 | H3GPN9 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Uncharacterized protein. | 0.933 |
H3G967_PHYRM | H3GWN7_PHYRM | H3G967 | H3GWN7 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.952 |
H3G967_PHYRM | H3H3C1_PHYRM | H3G967 | H3H3C1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | ATP-grasp domain-containing protein. | 0.991 |
H3G967_PHYRM | H3HA59_PHYRM | H3G967 | H3HA59 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Uncharacterized protein. | 0.884 |
H3G967_PHYRM | H3HC90_PHYRM | H3G967 | H3HC90 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | FSH1 domain-containing protein. | 0.876 |
H3G9E0_PHYRM | H3G8D7_PHYRM | H3G9E0 | H3G8D7 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.896 |
H3G9E0_PHYRM | H3G967_PHYRM | H3G9E0 | H3G967 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.997 |
H3G9E0_PHYRM | H3GN18_PHYRM | H3G9E0 | H3GN18 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.996 |