H3GS15_PHYRM protein (Phytophthora ramorum) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

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Score

H3GS15_PHYRM

Uncharacterized protein. (654 aa)

Predicted Functional Partners:

H3GUY2_PHYRM

0.707

H3HB77_PHYRM

0.707

H3G8A8_PHYRM

0.696

H3G9Y1_PHYRM

0.696

H3GBZ8_PHYRM

0.677

H3H2V3_PHYRM

0.666

H3G536_PHYRM

0.543

H3GF06_PHYRM

0.528

H3GQA2_PHYRM

0.525

H3HA71_PHYRM

0.525

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G536_PHYRM	H3GS15_PHYRM	H3G536	H3GS15	Uncharacterized protein.	Uncharacterized protein.	0.543
H3G8A8_PHYRM	H3GS15_PHYRM	H3G8A8	H3GS15	Uncharacterized protein.	Uncharacterized protein.	0.696
H3G9Y1_PHYRM	H3GS15_PHYRM	H3G9Y1	H3GS15	Uncharacterized protein.	Uncharacterized protein.	0.696
H3GBZ8_PHYRM	H3GQA2_PHYRM	H3GBZ8	H3GQA2	Spindle pole body component.	Tubulin domain-containing protein; Belongs to the tubulin family.	0.903
H3GBZ8_PHYRM	H3GS15_PHYRM	H3GBZ8	H3GS15	Spindle pole body component.	Uncharacterized protein.	0.677
H3GBZ8_PHYRM	H3GUY2_PHYRM	H3GBZ8	H3GUY2	Spindle pole body component.	Uncharacterized protein.	0.970
H3GBZ8_PHYRM	H3H2V3_PHYRM	H3GBZ8	H3H2V3	Spindle pole body component.	Uncharacterized protein.	0.978
H3GBZ8_PHYRM	H3HA71_PHYRM	H3GBZ8	H3HA71	Spindle pole body component.	Tubulin domain-containing protein; Belongs to the tubulin family.	0.903
H3GBZ8_PHYRM	H3HB77_PHYRM	H3GBZ8	H3HB77	Spindle pole body component.	Spindle pole body component.	0.986
H3GF06_PHYRM	H3GS15_PHYRM	H3GF06	H3GS15	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.528
H3GQA2_PHYRM	H3GBZ8_PHYRM	H3GQA2	H3GBZ8	Tubulin domain-containing protein; Belongs to the tubulin family.	Spindle pole body component.	0.903
H3GQA2_PHYRM	H3GS15_PHYRM	H3GQA2	H3GS15	Tubulin domain-containing protein; Belongs to the tubulin family.	Uncharacterized protein.	0.525
H3GQA2_PHYRM	H3GUY2_PHYRM	H3GQA2	H3GUY2	Tubulin domain-containing protein; Belongs to the tubulin family.	Uncharacterized protein.	0.884
H3GQA2_PHYRM	H3H2V3_PHYRM	H3GQA2	H3H2V3	Tubulin domain-containing protein; Belongs to the tubulin family.	Uncharacterized protein.	0.926
H3GQA2_PHYRM	H3HB77_PHYRM	H3GQA2	H3HB77	Tubulin domain-containing protein; Belongs to the tubulin family.	Spindle pole body component.	0.884
H3GS15_PHYRM	H3G536_PHYRM	H3GS15	H3G536	Uncharacterized protein.	Uncharacterized protein.	0.543
H3GS15_PHYRM	H3G8A8_PHYRM	H3GS15	H3G8A8	Uncharacterized protein.	Uncharacterized protein.	0.696
H3GS15_PHYRM	H3G9Y1_PHYRM	H3GS15	H3G9Y1	Uncharacterized protein.	Uncharacterized protein.	0.696
H3GS15_PHYRM	H3GBZ8_PHYRM	H3GS15	H3GBZ8	Uncharacterized protein.	Spindle pole body component.	0.677
H3GS15_PHYRM	H3GF06_PHYRM	H3GS15	H3GF06	Uncharacterized protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.528

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

3.86e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

8 of 82

1.26

1.64

5.36e-07

GO:0007165

Signal transduction

9 of 122

1.14

1.4

5.36e-07

GO:0019538

Protein metabolic process

8 of 194

0.88

0.84

5.34e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 39

1.52

2.26

1.94e-07

GO:0000155

Phosphorelay sensor kinase activity

6 of 35

1.5

2.0

2.21e-06

GO:0140096

Catalytic activity, acting on a protein

9 of 109

1.19

1.54

1.80e-07

GO:0016740

Transferase activity

8 of 304

0.69

0.54

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2313

Phosphorelay signal transduction system, and GGDEF domain

6 of 72

1.19

1.17

0.00018

CL:2397

PAC motif, and Putative diguanylate phosphodiesterase

3 of 12

1.67

1.17

0.0034

CL:2309

Signal transduction, and Flagellar assembly

8 of 171

0.94

0.87

0.00018

CL:2400

Mixed, incl. PAS domain, and SsuA/THI5-like

2 of 6

1.79

0.78

0.0310

CL:2317

Phosphorelay signal transduction system

3 of 29

1.28

0.7

0.0250

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

5 of 58

1.2

0.98

0.0019

KW-0597

Phosphoprotein

5 of 63

1.17

0.95

0.0019

KW-0175

Coiled coil

7 of 254

0.71

0.51

0.0070

KW-0808

Transferase

6 of 237

0.67

0.4

0.0359

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 29

1.65

2.73

2.51e-08

IPR003594

Histidine kinase/HSP90-like ATPase

8 of 40

1.57

2.65

6.63e-09

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 41

1.56

2.62

6.63e-09

IPR005467

Histidine kinase domain

7 of 37

1.55

2.38

8.52e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 35

1.5

1.96

3.24e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

8 of 39

1.58

2.89

4.69e-10

SM00388

His Kinase A (phosphoacceptor) domain

5 of 35

1.42

1.61

3.40e-05

SM00448

cheY-homologous receiver domain

5 of 55

1.23

1.21

0.00018

SM00091

PAS domain

3 of 21

1.42

1.03

0.0040

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 21

1.42

1.03

0.0040

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