H3GSJ4_PHYRM protein (Phytophthora ramorum) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Score

H3GSJ4_PHYRM

Uncharacterized protein. (983 aa)

Predicted Functional Partners:

H3GCA4_PHYRM

0.673

H3GG69_PHYRM

0.673

H3GRX8_PHYRM

0.673

H3GUA0_PHYRM

0.673

H3GUL4_PHYRM

0.673

H3H2X3_PHYRM

0.673

H3H3E7_PHYRM

0.673

H3H8Q3_PHYRM

0.673

H3HB89_PHYRM

0.673

H3HCY3_PHYRM

0.673

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3GCA4_PHYRM	H3GG69_PHYRM	H3GCA4	H3GG69	Uncharacterized protein.	Uncharacterized protein.	0.617
H3GCA4_PHYRM	H3GSJ4_PHYRM	H3GCA4	H3GSJ4	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GCA4_PHYRM	H3H3E7_PHYRM	H3GCA4	H3H3E7	Uncharacterized protein.	GPHH domain-containing protein.	0.540
H3GG69_PHYRM	H3GCA4_PHYRM	H3GG69	H3GCA4	Uncharacterized protein.	Uncharacterized protein.	0.617
H3GG69_PHYRM	H3GSJ4_PHYRM	H3GG69	H3GSJ4	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GG69_PHYRM	H3H3E7_PHYRM	H3GG69	H3H3E7	Uncharacterized protein.	GPHH domain-containing protein.	0.628
H3GRX8_PHYRM	H3GSJ4_PHYRM	H3GRX8	H3GSJ4	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GSJ4_PHYRM	H3GCA4_PHYRM	H3GSJ4	H3GCA4	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GSJ4_PHYRM	H3GG69_PHYRM	H3GSJ4	H3GG69	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GSJ4_PHYRM	H3GRX8_PHYRM	H3GSJ4	H3GRX8	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GSJ4_PHYRM	H3GUA0_PHYRM	H3GSJ4	H3GUA0	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GSJ4_PHYRM	H3GUL4_PHYRM	H3GSJ4	H3GUL4	Uncharacterized protein.	EF-hand domain-containing protein.	0.673
H3GSJ4_PHYRM	H3H2X3_PHYRM	H3GSJ4	H3H2X3	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GSJ4_PHYRM	H3H3E7_PHYRM	H3GSJ4	H3H3E7	Uncharacterized protein.	GPHH domain-containing protein.	0.673
H3GSJ4_PHYRM	H3H8Q3_PHYRM	H3GSJ4	H3H8Q3	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GSJ4_PHYRM	H3HB89_PHYRM	H3GSJ4	H3HB89	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GSJ4_PHYRM	H3HCY3_PHYRM	H3GSJ4	H3HCY3	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GUA0_PHYRM	H3GSJ4_PHYRM	H3GUA0	H3GSJ4	Uncharacterized protein.	Uncharacterized protein.	0.673
H3GUL4_PHYRM	H3GSJ4_PHYRM	H3GUL4	H3GSJ4	EF-hand domain-containing protein.	Uncharacterized protein.	0.673
H3H2X3_PHYRM	H3GSJ4_PHYRM	H3H2X3	H3GSJ4	Uncharacterized protein.	Uncharacterized protein.	0.673

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.905

expected number of edges:

17

PPI enrichment p-value:

0.0865

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032224

Positive regulation of synaptic transmission, cholinergic

3 of 5

3.1

2.82

7.57e-06

GO:0045995

Regulation of embryonic development

4 of 61

2.13

2.33

2.24e-05

GO:0000904

Cell morphogenesis involved in differentiation

7 of 515

1.45

1.89

2.56e-06

GO:0009887

Animal organ morphogenesis

8 of 749

1.35

1.74

1.71e-06

GO:0007411

Axon guidance

5 of 249

1.62

1.74

7.22e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005201

Extracellular matrix structural constituent

6 of 134

1.97

3.22

5.71e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005604

Basement membrane

8 of 77

2.33

6.55

5.35e-15

GO:0031012

Extracellular matrix

9 of 489

1.58

3.08

3.42e-11

GO:0043083

Synaptic cleft

3 of 9

2.84

2.95

3.81e-06

GO:0031594

Neuromuscular junction

3 of 44

2.15

1.86

0.00024

GO:0042383

Sarcolemma

3 of 77

1.91

1.49

0.0010

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36142434

(2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii).

3 of 13

2.68

2.39

3.80e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21899

MET activates PTK2 signaling, and Regulation of synaptic transmission, cholinergic

8 of 14

3.07

10.0

1.42e-19

CL:21782

ECM-receptor interaction, and Laminin interactions

9 of 77

2.39

7.74

8.90e-18

CL:21901

MET activates PTK2 signaling, and Regulation of synaptic transmission, cholinergic

4 of 7

3.07

4.56

4.34e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04512

ECM-receptor interaction

5 of 84

2.09

3.38

6.00e-08

pret04510

Focal adhesion

5 of 212

1.69

2.26

2.69e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3000157

Laminin interactions

8 of 40

2.62

8.04

5.57e-17

MAP-8874081

MET activates PTK2 signaling

5 of 22

2.67

4.84

5.93e-10

MAP-8875878

MET promotes cell motility

5 of 38

2.44

4.23

4.69e-09

MAP-6806834

Signaling by MET

5 of 78

2.12

3.36

8.42e-08

MAP-3000171

Non-integrin membrane-ECM interactions

4 of 51

2.21

2.79

2.70e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

3 of 407

1.19

0.81

0.0076

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005604

Basement membrane

8 of 56

2.47

7.27

6.00e-16

GOCC:0062023

Collagen-containing extracellular matrix

9 of 190

1.99

5.33

9.90e-15

GOCC:0005610

laminin-5 complex

4 of 7

3.07

4.6

3.65e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0424

Laminin EGF-like domain

5 of 38

2.44

4.33

2.83e-09

KW-1015

Disulfide bond

5 of 1351

0.89

0.49

0.0415

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002049

Laminin-type EGF domain

6 of 51

2.39

4.58

5.94e-10

IPR000034

Laminin IV

4 of 6

3.14

4.2

2.16e-08

IPR008211

Laminin, N-terminal

4 of 23

2.56

3.14

1.20e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00180

Laminin-type epidermal growth factor-like domai

6 of 42

2.47

5.32

2.20e-11

SM00136

Laminin N-terminal domain (domain VI)

4 of 22

2.58

3.57

1.67e-07

SM00001

EGF domain, unclasssified subfamily

4 of 92

1.96

2.21

2.44e-05

SM00281

Laminin B domain

2 of 4

3.02

1.78

0.00061

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