H3H3N6_PHYRM protein (Phytophthora ramorum) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

H3H3N6_PHYRM

Uncharacterized protein. (399 aa)

Predicted Functional Partners:

H3GMK0_PHYRM

0.626

H3G8X1_PHYRM

0.607

H3G7L0_PHYRM

0.576

H3G6M4_PHYRM

0.560

H3GSZ7_PHYRM

0.560

H3G8X4_PHYRM

0.555

H3HD97_PHYRM

0.530

H3G5R2_PHYRM

0.459

H3G9A3_PHYRM

0.459

H3GBV9_PHYRM

0.448

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G5R2_PHYRM	H3G6M4_PHYRM	H3G5R2	H3G6M4	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.857
H3G5R2_PHYRM	H3G7L0_PHYRM	H3G5R2	H3G7L0	Protein kinase domain-containing protein.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.905
H3G5R2_PHYRM	H3GMK0_PHYRM	H3G5R2	H3GMK0	Protein kinase domain-containing protein.	Uncharacterized protein.	0.404
H3G5R2_PHYRM	H3GSZ7_PHYRM	H3G5R2	H3GSZ7	Protein kinase domain-containing protein.	Serine/threonine-protein kinase PLK.	0.857
H3G5R2_PHYRM	H3H3N6_PHYRM	H3G5R2	H3H3N6	Protein kinase domain-containing protein.	Uncharacterized protein.	0.459
H3G5R2_PHYRM	H3HD97_PHYRM	H3G5R2	H3HD97	Protein kinase domain-containing protein.	Uncharacterized protein.	0.765
H3G6M4_PHYRM	H3G5R2_PHYRM	H3G6M4	H3G5R2	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.857
H3G6M4_PHYRM	H3G7L0_PHYRM	H3G6M4	H3G7L0	Protein kinase domain-containing protein.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.931
H3G6M4_PHYRM	H3G9A3_PHYRM	H3G6M4	H3G9A3	Protein kinase domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.874
H3G6M4_PHYRM	H3GMK0_PHYRM	H3G6M4	H3GMK0	Protein kinase domain-containing protein.	Uncharacterized protein.	0.441
H3G6M4_PHYRM	H3H3N6_PHYRM	H3G6M4	H3H3N6	Protein kinase domain-containing protein.	Uncharacterized protein.	0.560
H3G6M4_PHYRM	H3HD97_PHYRM	H3G6M4	H3HD97	Protein kinase domain-containing protein.	Uncharacterized protein.	0.977
H3G7L0_PHYRM	H3G5R2_PHYRM	H3G7L0	H3G5R2	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Protein kinase domain-containing protein.	0.905
H3G7L0_PHYRM	H3G6M4_PHYRM	H3G7L0	H3G6M4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Protein kinase domain-containing protein.	0.931
H3G7L0_PHYRM	H3G9A3_PHYRM	H3G7L0	H3G9A3	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.905
H3G7L0_PHYRM	H3GMK0_PHYRM	H3G7L0	H3GMK0	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Uncharacterized protein.	0.561
H3G7L0_PHYRM	H3GSZ7_PHYRM	H3G7L0	H3GSZ7	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Serine/threonine-protein kinase PLK.	0.931
H3G7L0_PHYRM	H3H3N6_PHYRM	H3G7L0	H3H3N6	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Uncharacterized protein.	0.576
H3G7L0_PHYRM	H3HD97_PHYRM	H3G7L0	H3HD97	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Uncharacterized protein.	0.947
H3G8X1_PHYRM	H3H3N6_PHYRM	H3G8X1	H3H3N6	Malate synthase; Belongs to the malate synthase family.	Uncharacterized protein.	0.607

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Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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