node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | H3G5W3_PHYRM | H3GAS1 | H3G5W3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | 0.980 |
FEN1 | H3G6X5_PHYRM | H3GAS1 | H3G6X5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.898 |
FEN1 | H3GAM4_PHYRM | H3GAS1 | H3GAM4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase. | 0.990 |
FEN1 | H3GCB9_PHYRM | H3GAS1 | H3GCB9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication protein A subunit. | 0.810 |
FEN1 | H3GG27_PHYRM | H3GAS1 | H3GG27 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.763 |
FEN1 | H3GGW5_PHYRM | H3GAS1 | H3GGW5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | WD_REPEATS_REGION domain-containing protein. | 0.689 |
FEN1 | H3GRJ3_PHYRM | H3GAS1 | H3GRJ3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.763 |
FEN1 | H3H5N9_PHYRM | H3GAS1 | H3H5N9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.898 |
FEN1 | H3HCP8_PHYRM | H3GAS1 | H3HCP8 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.763 |
FEN1 | H3HE99_PHYRM | H3GAS1 | H3HE99 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.763 |
H3G5W3_PHYRM | FEN1 | H3G5W3 | H3GAS1 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.980 |
H3G5W3_PHYRM | H3G6X5_PHYRM | H3G5W3 | H3G6X5 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.808 |
H3G5W3_PHYRM | H3GAM4_PHYRM | H3G5W3 | H3GAM4 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | DNA polymerase. | 0.758 |
H3G5W3_PHYRM | H3GCB9_PHYRM | H3G5W3 | H3GCB9 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Replication protein A subunit. | 0.969 |
H3G5W3_PHYRM | H3GG27_PHYRM | H3G5W3 | H3GG27 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.934 |
H3G5W3_PHYRM | H3GRJ3_PHYRM | H3G5W3 | H3GRJ3 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.934 |
H3G5W3_PHYRM | H3H5N9_PHYRM | H3G5W3 | H3H5N9 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.808 |
H3G5W3_PHYRM | H3HCP8_PHYRM | H3G5W3 | H3HCP8 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.934 |
H3G5W3_PHYRM | H3HE99_PHYRM | H3G5W3 | H3HE99 | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | Uncharacterized protein. | 0.934 |
H3G6X5_PHYRM | FEN1 | H3G6X5 | H3GAS1 | Uncharacterized protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.898 |