H3HEC7_PHYRM protein (Phytophthora ramorum) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

H3HEC7_PHYRM

Uncharacterized protein. (199 aa)

Predicted Functional Partners:

H3G693_PHYRM

0.639

H3GT76_PHYRM

0.639

H3GS60_PHYRM

0.622

H3H0Z3_PHYRM

0.622

H3GAR2_PHYRM

0.612

H3G768_PHYRM

0.603

H3G969_PHYRM

0.603

H3GE10_PHYRM

0.603

H3GAE2_PHYRM

0.597

H3GFW5_PHYRM

0.582

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G693_PHYRM	H3GAE2_PHYRM	H3G693	H3GAE2	SER_THR_PHOSPHATASE domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.465
H3G693_PHYRM	H3GAR2_PHYRM	H3G693	H3GAR2	SER_THR_PHOSPHATASE domain-containing protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.728
H3G693_PHYRM	H3HEC7_PHYRM	H3G693	H3HEC7	SER_THR_PHOSPHATASE domain-containing protein.	Uncharacterized protein.	0.639
H3G768_PHYRM	H3GAR2_PHYRM	H3G768	H3GAR2	Uncharacterized protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.560
H3G768_PHYRM	H3GE10_PHYRM	H3G768	H3GE10	Uncharacterized protein.	Uncharacterized protein.	0.430
H3G768_PHYRM	H3GFW5_PHYRM	H3G768	H3GFW5	Uncharacterized protein.	Uncharacterized protein.	0.859
H3G768_PHYRM	H3HEC7_PHYRM	H3G768	H3HEC7	Uncharacterized protein.	Uncharacterized protein.	0.603
H3G969_PHYRM	H3GAR2_PHYRM	H3G969	H3GAR2	Uncharacterized protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.560
H3G969_PHYRM	H3GFW5_PHYRM	H3G969	H3GFW5	Uncharacterized protein.	Uncharacterized protein.	0.859
H3G969_PHYRM	H3HEC7_PHYRM	H3G969	H3HEC7	Uncharacterized protein.	Uncharacterized protein.	0.603
H3GAE2_PHYRM	H3G693_PHYRM	H3GAE2	H3G693	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	SER_THR_PHOSPHATASE domain-containing protein.	0.465
H3GAE2_PHYRM	H3GT76_PHYRM	H3GAE2	H3GT76	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Serine/threonine-protein phosphatase.	0.465
H3GAE2_PHYRM	H3HEC7_PHYRM	H3GAE2	H3HEC7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.597
H3GAR2_PHYRM	H3G693_PHYRM	H3GAR2	H3G693	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	SER_THR_PHOSPHATASE domain-containing protein.	0.728
H3GAR2_PHYRM	H3G768_PHYRM	H3GAR2	H3G768	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	Uncharacterized protein.	0.560
H3GAR2_PHYRM	H3G969_PHYRM	H3GAR2	H3G969	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	Uncharacterized protein.	0.560
H3GAR2_PHYRM	H3GE10_PHYRM	H3GAR2	H3GE10	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	Uncharacterized protein.	0.560
H3GAR2_PHYRM	H3GT76_PHYRM	H3GAR2	H3GT76	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	Serine/threonine-protein phosphatase.	0.728
H3GAR2_PHYRM	H3HEC7_PHYRM	H3GAR2	H3HEC7	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	Uncharacterized protein.	0.612
H3GE10_PHYRM	H3G768_PHYRM	H3GE10	H3G768	Uncharacterized protein.	Uncharacterized protein.	0.430

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.849

expected number of edges:

11

PPI enrichment p-value:

1.04e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

11 of 41

1.98

6.18

1.06e-18

GO:0000160

Phosphorelay signal transduction system

10 of 34

2.02

6.02

4.17e-17

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

8 of 13

2.34

6.34

1.92e-14

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 133

1.38

2.28

4.31e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 760

0.62

0.48

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2926

Two-component regulatory system, and Histidine kinase domain

10 of 23

2.18

7.21

1.41e-18

CL:2928

Two-component regulatory system, and Histidine kinase domain

9 of 18

2.25

6.93

6.92e-17

CL:2931

Two-component regulatory system, and PAS domain

8 of 12

2.37

6.82

1.80e-15

CL:2923

Phosphorelay signal transduction system, and P-type ion transporter activity

11 of 35

2.04

6.74

1.59e-19

CL:2933

Histidine kinase domain, and Transcriptional regulatory protein, C terminal

3 of 5

2.32

2.12

9.31e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aka02020

Two-component system

4 of 79

1.25

0.87

0.0063

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 67

1.67

3.58

2.78e-12

KW-0902

Two-component regulatory system

4 of 14

2.0

2.46

7.00e-06

KW-0067

ATP-binding

6 of 232

0.96

0.81

0.00089

KW-0597

Phosphoprotein

2 of 22

1.51

0.67

0.0435

KW-1133

Transmembrane helix

8 of 684

0.61

0.47

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

9 of 11

2.46

7.81

2.22e-17

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

9 of 12

2.42

7.7

2.22e-17

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 12

2.42

7.7

2.22e-17

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

8 of 11

2.41

6.82

3.22e-15

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 11

2.41

6.82

3.22e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

9 of 11

2.46

8.28

1.41e-18

SM00388

His Kinase A (phosphoacceptor) domain

8 of 11

2.41

7.18

4.08e-16

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

4 of 4

2.55

3.75

6.79e-08

SM00091

PAS domain

2 of 3

2.37

1.52

0.0015

SM00862

Transcriptional regulatory protein, C terminal

2 of 12

1.77

0.99

0.0109

(more ...)

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