ypcH protein (Erysipelothrix rhusiopathiae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

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[Homology]

Score

ypcH

Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)

Predicted Functional Partners:

AMS11751.1

0.997

ypcG

0.993

AMS10776.1

0.928

AMS11575.1

0.882

YesN

0.881

msmK

0.866

YesM

0.858

AMS11741.1

0.782

AMS10775.1

0.740

AMS11135.1

0.678

Your Current Organism:

Erysipelothrix rhusiopathiae

NCBI taxonomy Id: 1648
Other names: ATCC 19414, Bacillus insidiosus, Bacillus rhusiopathiae suis, Bacterium rhusiopathiae, CCUG 221, CIP 105957, DSM 5055, E. rhusiopathiae, Erysipelothrix erysipeloides, Erysipelothrix insidiosa, Erysipelothrix murisepticus, Erysipelothrix porci, NCTC 8163

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMS10775.1	AMS10776.1	A2I91_03070	A2I91_03075	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetylneuraminate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.939
AMS10775.1	AMS11135.1	A2I91_03070	A2I91_05135	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.665
AMS10775.1	AMS11575.1	A2I91_03070	A2I91_07420	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.699
AMS10775.1	msmK	A2I91_03070	A2I91_08515	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.665
AMS10775.1	ypcH	A2I91_03070	A2I91_08370	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.740
AMS10776.1	AMS10775.1	A2I91_03075	A2I91_03070	Acetylneuraminate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.939
AMS10776.1	AMS11135.1	A2I91_03075	A2I91_05135	Acetylneuraminate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.835
AMS10776.1	AMS11751.1	A2I91_03075	A2I91_08375	Acetylneuraminate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.623
AMS10776.1	msmK	A2I91_03075	A2I91_08515	Acetylneuraminate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.944
AMS10776.1	ypcG	A2I91_03075	A2I91_08365	Acetylneuraminate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.672
AMS10776.1	ypcH	A2I91_03075	A2I91_08370	Acetylneuraminate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.928
AMS11135.1	AMS10775.1	A2I91_05135	A2I91_03070	Spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.665
AMS11135.1	AMS10776.1	A2I91_05135	A2I91_03075	Spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Acetylneuraminate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.835
AMS11135.1	AMS11575.1	A2I91_05135	A2I91_07420	Spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.834
AMS11135.1	ypcG	A2I91_05135	A2I91_08365	Spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.660
AMS11135.1	ypcH	A2I91_05135	A2I91_08370	Spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.678
AMS11575.1	AMS10775.1	A2I91_07420	A2I91_03070	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.699
AMS11575.1	AMS11135.1	A2I91_07420	A2I91_05135	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.834
AMS11575.1	msmK	A2I91_07420	A2I91_08515	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.940
AMS11575.1	ypcG	A2I91_07420	A2I91_08365	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.672

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Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.826

expected number of edges:

12

PPI enrichment p-value:

1.85e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042274

Ribosomal small subunit biogenesis

6 of 82

2.23

4.13

2.29e-09

GO:0006412

Translation

7 of 363

1.65

2.66

4.73e-08

GO:0030490

Maturation of SSU-rRNA

4 of 67

2.14

2.6

5.68e-06

GO:0006364

rRNA processing

5 of 268

1.64

1.99

1.31e-05

GO:0000462

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

3 of 52

2.13

1.86

0.00024

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

7 of 183

1.95

3.84

5.95e-10

GO:0030515

snoRNA binding

2 of 23

2.3

0.92

0.0206

GO:0003723

RNA binding

5 of 763

1.18

0.85

0.0053

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022627

Cytosolic small ribosomal subunit

5 of 27

2.63

4.96

2.91e-10

GO:0015935

Small ribosomal subunit

6 of 59

2.37

4.94

8.00e-11

GO:0005840

Ribosome

7 of 202

1.91

3.83

2.91e-10

GO:1990904

Ribonucleoprotein complex

8 of 551

1.53

2.65

1.59e-09

GO:0030684

Preribosome

4 of 107

1.94

2.35

9.86e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10688

Cytosolic small ribosomal subunit, and Ribosomal protein S8

5 of 13

2.95

5.34

1.20e-10

CL:11902

Preribosome, small subunit precursor

3 of 5

3.14

3.45

5.25e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

7 of 217

1.87

3.81

1.81e-10

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

8 of 182

2.01

4.81

1.23e-12

MAP-8868773

rRNA processing in the nucleus and cytosol

8 of 185

2.0

4.79

1.23e-12

MAP-72312

rRNA processing

8 of 188

1.99

4.76

1.23e-12

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

6 of 103

2.13

4.25

4.48e-10

MAP-72702

Ribosomal scanning and start codon recognition

6 of 124

2.05

3.96

1.10e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015935

Small ribosomal subunit

7 of 73

2.35

5.74

7.38e-13

GOCC:0022627

Cytosolic small ribosomal subunit

6 of 39

2.55

5.72

4.85e-12

GOCC:1990904

Ribonucleoprotein complex

9 of 532

1.59

3.18

1.42e-11

GOCC:0030684

Preribosome

3 of 83

1.92

1.62

0.00054

GOCC:0030688

Preribosome, small subunit precursor

2 of 14

2.52

1.5

0.0017

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 107

2.18

5.19

2.26e-12

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03719

Ribosomal protein S5, C-terminal domain

2 of 2

3.37

1.62

0.0012

PF00333

Ribosomal protein S5, N-terminal domain

2 of 2

3.37

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013810

Ribosomal protein S5, N-terminal

2 of 2

3.37

1.39

0.0032

IPR005324

Ribosomal protein S5, C-terminal

2 of 2

3.37

1.39

0.0032

IPR000851

Ribosomal protein S5

2 of 2

3.37

1.39

0.0032

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

2 of 19

2.39

0.85

0.0279

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