STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THC_0776Riboflavin synthase subunit alpha. (219 aa)    
Predicted Functional Partners:
THC_1132
DeoR faimly transcriptional regulator; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
 0.999
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 
 0.999
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.998
THC_0111
5-amino-6-(5-phosphoribosylamino)uracil reductase.
 
  
 0.934
THC_1224
Riboflavin biosynthesis protein RibF; Belongs to the ribF family.
  
 
 0.925
THC_0996
Pyridine nucleotide-disulfide oxidoreductase.
   
    0.904
rpmE
50S ribosomal protein L31; Binds the 23S rRNA.
   
    0.751
trpF
N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family.
  
    0.682
THC_0777
Hypothetical protein.
       0.678
nadE
NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.447
Your Current Organism:
Caldimicrobium thiodismutans
NCBI taxonomy Id: 1653476
Other names: C. thiodismutans, Caldimicrobium thiodismutans Kojima et al. 2016, DSM 29380, NBRC 110713, Thermodesulfobacteriaceae bacterium TF1, strain TF1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.