STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (187 aa)    
Predicted Functional Partners:
OLO90797.1
Aminopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      0.899
OLO90762.1
Pyrroline-5-carboxylate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      0.837
OLO90814.1
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
  
 
 0.819
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.711
hemL
Aspartate aminotransferase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
      0.684
OLO91193.1
Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.647
OLO90202.1
Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.647
OLO89670.1
Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.647
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.638
OLO90105.1
ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.623
Your Current Organism:
Actinomyces naeslundii
NCBI taxonomy Id: 1655
Other names: A. naeslundii, ATCC 12104, CCUG 18310, CCUG 2238, CCUG 32832, CCUG 35333, CDC W826, CIP 103128, DSM 43013, JCM 8349, NCTC 10301
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