icd protein (Synechococcus sp. WH 8109) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

icd

Isocitrate dehydrogenase. (474 aa)

Predicted Functional Partners:

acnB

0.985

gltA

0.978

gcvP

0.925

purB

0.822

aspC

0.818

nadB

0.813

argH

0.811

leuB

0.802

ndhK

0.699

AHF63691.1

0.687

Your Current Organism:

Synechococcus sp. WH 8109

NCBI taxonomy Id: 166314
Other names: S. sp. WH 8109, Synechococcus sp. WH8109

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHF63691.1	acnB	Syncc8109_1327	Syncc8109_2737	Hypothetical protein.	Aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family.	0.447
AHF63691.1	gcvP	Syncc8109_1327	Syncc8109_2615	Hypothetical protein.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.845
AHF63691.1	gltA	Syncc8109_1327	Syncc8109_2523	Hypothetical protein.	2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.	0.822
AHF63691.1	icd	Syncc8109_1327	Syncc8109_0169	Hypothetical protein.	Isocitrate dehydrogenase.	0.687
AHF63691.1	ndhK	Syncc8109_1327	Syncc8109_0197	Hypothetical protein.	NADH-quinone oxidoreductase, B subunit; NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration; Belongs to the complex I 20 kDa subunit family.	0.631
acnB	AHF63691.1	Syncc8109_2737	Syncc8109_1327	Aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family.	Hypothetical protein.	0.447
acnB	gltA	Syncc8109_2737	Syncc8109_2523	Aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family.	2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.	0.961
acnB	icd	Syncc8109_2737	Syncc8109_0169	Aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family.	Isocitrate dehydrogenase.	0.985
argH	gcvP	Syncc8109_0014	Syncc8109_2615	Argininosuccinate lyase.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.578
argH	gltA	Syncc8109_0014	Syncc8109_2523	Argininosuccinate lyase.	2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.	0.814
argH	icd	Syncc8109_0014	Syncc8109_0169	Argininosuccinate lyase.	Isocitrate dehydrogenase.	0.811
argH	purB	Syncc8109_0014	Syncc8109_2289	Argininosuccinate lyase.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.915
aspC	gltA	Syncc8109_1393	Syncc8109_2523	Aminotransferases class-I.	2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.	0.822
aspC	icd	Syncc8109_1393	Syncc8109_0169	Aminotransferases class-I.	Isocitrate dehydrogenase.	0.818
aspC	nadB	Syncc8109_1393	Syncc8109_2430	Aminotransferases class-I.	L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.	0.814
gcvP	AHF63691.1	Syncc8109_2615	Syncc8109_1327	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Hypothetical protein.	0.845
gcvP	argH	Syncc8109_2615	Syncc8109_0014	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Argininosuccinate lyase.	0.578
gcvP	gltA	Syncc8109_2615	Syncc8109_2523	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.	0.456
gcvP	icd	Syncc8109_2615	Syncc8109_0169	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Isocitrate dehydrogenase.	0.925
gcvP	leuB	Syncc8109_2615	Syncc8109_0815	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.580