| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AHF64439.1 | gcsH | Syncc8109_2101 | Syncc8109_2616 | Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.794 |
| AHF64439.1 | gcvP | Syncc8109_2101 | Syncc8109_2615 | Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.671 |
| AHF64439.1 | gcvT | Syncc8109_2101 | Syncc8109_2659 | Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.609 |
| AHF64439.1 | lpdA | Syncc8109_2101 | Syncc8109_1861 | Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate. | Putative dihydrolipoamide dehydrogenase. | 0.999 |
| AHF64439.1 | pdhA | Syncc8109_2101 | Syncc8109_1849 | Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate. | Pyruvate dehydrogenase (lipoamide); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.999 |
| AHF64439.1 | pdhB | Syncc8109_2101 | Syncc8109_1491 | Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate. | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
| AHF64821.1 | folD | Syncc8109_2514 | Syncc8109_2024 | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
| AHF64821.1 | gcsH | Syncc8109_2514 | Syncc8109_2616 | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.932 |
| AHF64821.1 | gcvP | Syncc8109_2514 | Syncc8109_2615 | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.964 |
| AHF64821.1 | gcvT | Syncc8109_2514 | Syncc8109_2659 | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.928 |
| AHF64821.1 | glyA | Syncc8109_2514 | Syncc8109_0252 | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.945 |
| AHF64821.1 | lpdA | Syncc8109_2514 | Syncc8109_1861 | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. | Putative dihydrolipoamide dehydrogenase. | 0.910 |
| folD | AHF64821.1 | Syncc8109_2024 | Syncc8109_2514 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. | 0.932 |
| folD | gcsH | Syncc8109_2024 | Syncc8109_2616 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.949 |
| folD | gcvP | Syncc8109_2024 | Syncc8109_2615 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.978 |
| folD | gcvT | Syncc8109_2024 | Syncc8109_2659 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.954 |
| folD | glyA | Syncc8109_2024 | Syncc8109_0252 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.981 |
| folD | lpdA | Syncc8109_2024 | Syncc8109_1861 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative dihydrolipoamide dehydrogenase. | 0.912 |
| gcsH | AHF64439.1 | Syncc8109_2616 | Syncc8109_2101 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate. | 0.794 |
| gcsH | AHF64821.1 | Syncc8109_2616 | Syncc8109_2514 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. | 0.932 |
