hrcA protein (Synechococcus sp. WH 8109) - STRING interaction network

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hrcA

Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (324 aa)

Predicted Functional Partners:

grpE

0.907

AHF64833.1

0.815

dnaK-3

0.702

dnaK

0.699

groEL2

0.656

groEL

0.653

AHF64832.1

0.637

groES

0.597

ribA/ribB

0.588

AHF64831.1

0.583

Your Current Organism:

Synechococcus sp. WH 8109

NCBI taxonomy Id: 166314
Other names: S. sp. WH 8109, Synechococcus sp. WH8109

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHF64831.1	AHF64832.1	Syncc8109_2524	Syncc8109_2525	Phosphohistidine phosphatase, SixA.	Hypothetical protein.	0.804
AHF64831.1	AHF64833.1	Syncc8109_2524	Syncc8109_2526	Phosphohistidine phosphatase, SixA.	Rhodanese-like protein.	0.570
AHF64831.1	hrcA	Syncc8109_2524	Syncc8109_2527	Phosphohistidine phosphatase, SixA.	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.583
AHF64832.1	AHF64831.1	Syncc8109_2525	Syncc8109_2524	Hypothetical protein.	Phosphohistidine phosphatase, SixA.	0.804
AHF64832.1	AHF64833.1	Syncc8109_2525	Syncc8109_2526	Hypothetical protein.	Rhodanese-like protein.	0.640
AHF64832.1	hrcA	Syncc8109_2525	Syncc8109_2527	Hypothetical protein.	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.637
AHF64833.1	AHF64831.1	Syncc8109_2526	Syncc8109_2524	Rhodanese-like protein.	Phosphohistidine phosphatase, SixA.	0.570
AHF64833.1	AHF64832.1	Syncc8109_2526	Syncc8109_2525	Rhodanese-like protein.	Hypothetical protein.	0.640
AHF64833.1	hrcA	Syncc8109_2526	Syncc8109_2527	Rhodanese-like protein.	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.815
dnaK	dnaK-3	Syncc8109_1268	Syncc8109_2744	Molecular chaperone DnaK, heat shock protein HSP70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.903
dnaK	groEL	Syncc8109_1268	Syncc8109_2250	Molecular chaperone DnaK, heat shock protein HSP70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.906
dnaK	groEL2	Syncc8109_1268	Syncc8109_0673	Molecular chaperone DnaK, heat shock protein HSP70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.906
dnaK	groES	Syncc8109_1268	Syncc8109_2251	Molecular chaperone DnaK, heat shock protein HSP70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.917
dnaK	grpE	Syncc8109_1268	Syncc8109_0022	Molecular chaperone DnaK, heat shock protein HSP70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Putative heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several round [...]	0.989
dnaK	hrcA	Syncc8109_1268	Syncc8109_2527	Molecular chaperone DnaK, heat shock protein HSP70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.699
dnaK-3	dnaK	Syncc8109_2744	Syncc8109_1268	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Molecular chaperone DnaK, heat shock protein HSP70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.903
dnaK-3	groEL	Syncc8109_2744	Syncc8109_2250	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.906
dnaK-3	groEL2	Syncc8109_2744	Syncc8109_0673	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.906
dnaK-3	groES	Syncc8109_2744	Syncc8109_2251	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.916
dnaK-3	grpE	Syncc8109_2744	Syncc8109_0022	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Putative heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several round [...]	0.990

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