STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (1006 aa)    
Predicted Functional Partners:
EHA59101.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 0.999
EHA60243.1
TIGRFAM: DNA helicase, ATP-dependent, RecQ type; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; KEGG: pmf:P9303_21731 superfamily II DNA helicase; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal.
  
 0.995
recA
Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.993
mutM
Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 0.988
EHA63027.1
Helicase domain protein; PFAM: Helicase, C-terminal; KEGG: pmf:P9303_08571 helicase domain-containing protein.
   
 0.987
EHA63213.1
Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: pmf:P9303_13291 DNA repair exonuclease.
   
 0.987
EHA63467.1
Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: pmj:P9211_07941 putative transcripton factor.
   
 0.987
EHA58636.1
Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: amr:AM1_2519 hypothetical protein.
   
 0.987
EHA59333.1
KEGG: pmf:P9303_22951 Rad3-related DNA helicase.
   
 0.985
EHA59175.1
KEGG: pmf:P9303_00881 DNA mismatch repair protein MutS; PFAM: DNA mismatch repair protein MutS, C-terminal; DNA mismatch repair protein MutS, clamp; DNA mismatch repair protein MutS, core; SMART: DNA mismatch repair protein MutS, C-terminal.
   
 0.985
Your Current Organism:
Synechococcus sp. WH 8016
NCBI taxonomy Id: 166318
Other names: S. sp. WH 8016, Synechococcus sp. WH8016
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