prfC protein (Synechococcus sp. WH 8016) - STRING interaction network

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prfC

Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (584 aa)

Predicted Functional Partners:

rpmA

0.852

rplS

0.822

EHA63283.1

0.816

rplT

0.812

prfA

0.808

rplL

0.805

rplM

0.798

rpmF

0.795

rplQ

0.792

rplI

0.788

Your Current Organism:

Synechococcus sp. WH 8016

NCBI taxonomy Id: 166318
Other names: S. sp. WH 8016, Synechococcus sp. WH8016

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHA63283.1	prfC	Syn8016DRAFT_0324	Syn8016DRAFT_0325	PFAM: Methyltransferase type 12; KEGG: pmt:PMT0792 hypothetical protein.	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	0.816
prfA	prfC	Syn8016DRAFT_2666	Syn8016DRAFT_0325	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	0.808
prfA	rplI	Syn8016DRAFT_2666	Syn8016DRAFT_2024	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	50S ribosomal protein L9; Binds to the 23S rRNA.	0.894
prfA	rplL	Syn8016DRAFT_2666	Syn8016DRAFT_1948	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.	0.716
prfA	rplM	Syn8016DRAFT_2666	Syn8016DRAFT_2669	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.966
prfA	rplQ	Syn8016DRAFT_2666	Syn8016DRAFT_2672	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	Ribosomal protein L17; KEGG: pmf:P9303_23271 50S ribosomal protein L17; TIGRFAM: Ribosomal protein L17; PFAM: Ribosomal protein L17.	0.920
prfA	rplS	Syn8016DRAFT_2666	Syn8016DRAFT_1404	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.902
prfA	rplT	Syn8016DRAFT_2666	Syn8016DRAFT_2878	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.907
prfA	rpmA	Syn8016DRAFT_2666	Syn8016DRAFT_1455	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	TIGRFAM: Ribosomal protein L27; HAMAP: Ribosomal protein L27; KEGG: pme:NATL1_17721 50S ribosomal protein L27; PFAM: Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.	0.933
prfA	rpmF	Syn8016DRAFT_2666	Syn8016DRAFT_0383	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	TIGRFAM: Ribosomal protein L32p; HAMAP: Ribosomal protein L32p; KEGG: pmf:P9303_14571 50S ribosomal protein L32; PFAM: Ribosomal protein L32p; Belongs to the bacterial ribosomal protein bL32 family.	0.868
prfC	EHA63283.1	Syn8016DRAFT_0325	Syn8016DRAFT_0324	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	PFAM: Methyltransferase type 12; KEGG: pmt:PMT0792 hypothetical protein.	0.816
prfC	prfA	Syn8016DRAFT_0325	Syn8016DRAFT_2666	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	0.808
prfC	rplI	Syn8016DRAFT_0325	Syn8016DRAFT_2024	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	50S ribosomal protein L9; Binds to the 23S rRNA.	0.788
prfC	rplL	Syn8016DRAFT_0325	Syn8016DRAFT_1948	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.	0.805
prfC	rplM	Syn8016DRAFT_0325	Syn8016DRAFT_2669	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.798
prfC	rplQ	Syn8016DRAFT_0325	Syn8016DRAFT_2672	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	Ribosomal protein L17; KEGG: pmf:P9303_23271 50S ribosomal protein L17; TIGRFAM: Ribosomal protein L17; PFAM: Ribosomal protein L17.	0.792
prfC	rplS	Syn8016DRAFT_0325	Syn8016DRAFT_1404	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.822
prfC	rplT	Syn8016DRAFT_0325	Syn8016DRAFT_2878	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.812
prfC	rpmA	Syn8016DRAFT_0325	Syn8016DRAFT_1455	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	TIGRFAM: Ribosomal protein L27; HAMAP: Ribosomal protein L27; KEGG: pme:NATL1_17721 50S ribosomal protein L27; PFAM: Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.	0.852
prfC	rpmF	Syn8016DRAFT_0325	Syn8016DRAFT_0383	Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	TIGRFAM: Ribosomal protein L32p; HAMAP: Ribosomal protein L32p; KEGG: pmf:P9303_14571 50S ribosomal protein L32; PFAM: Ribosomal protein L32p; Belongs to the bacterial ribosomal protein bL32 family.	0.795

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