EHA63682.1 protein (Synechococcus sp. WH 8016)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

EHA63682.1

DNA-directed DNA polymerase; KEGG: pmt:PMT0638 putative UmuC protein; PFAM: DNA-repair protein, UmuC-like. (424 aa)

Predicted Functional Partners:

EHA63681.1

0.996

recA

0.965

EHA59101.1

0.961

lexA

0.927

EHA63703.1

0.912

polA

0.798

EHA63628.1

0.766

EHA59173.1

0.766

EHA61763.1

0.748

EHA63217.1

0.734

Your Current Organism:

Synechococcus sp. WH 8016

NCBI taxonomy Id: 166318
Other names: S. sp. WH 8016, Synechococcus sp. WH8016

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHA59101.1	EHA59173.1	Syn8016DRAFT_2824	Syn8016DRAFT_2896	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	0.994
EHA59101.1	EHA61763.1	Syn8016DRAFT_2824	Syn8016DRAFT_1835	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: pmf:P9303_26481 DNA polymerase III subunit delta'.	0.988
EHA59101.1	EHA63217.1	Syn8016DRAFT_2824	Syn8016DRAFT_0258	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	KEGG: pmt:PMT0874 hypothetical protein.	0.888
EHA59101.1	EHA63628.1	Syn8016DRAFT_2824	Syn8016DRAFT_0669	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	KEGG: pmt:PMT0386 putative DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T/DNA polymerase III; SMART: Exonuclease.	0.945
EHA59101.1	EHA63681.1	Syn8016DRAFT_2824	Syn8016DRAFT_0722	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	PFAM: Peptidase S24/S26A/S26B, conserved region; KEGG: pmf:P9303_16001 putative SOS mutagenesis protein UmuD; Belongs to the peptidase S24 family.	0.728
EHA59101.1	EHA63682.1	Syn8016DRAFT_2824	Syn8016DRAFT_0723	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA-directed DNA polymerase; KEGG: pmt:PMT0638 putative UmuC protein; PFAM: DNA-repair protein, UmuC-like.	0.961
EHA59101.1	EHA63703.1	Syn8016DRAFT_2824	Syn8016DRAFT_0744	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase III, alpha subunit; SMART: Polymerase/histidinol phosphatase, N-terminal; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: pmt:PMT0647 DNA polymerase III subunit alpha; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type.	0.984
EHA59101.1	lexA	Syn8016DRAFT_2824	Syn8016DRAFT_0015	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.768
EHA59101.1	polA	Syn8016DRAFT_2824	Syn8016DRAFT_0084	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.994
EHA59101.1	recA	Syn8016DRAFT_2824	Syn8016DRAFT_2700	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.941
EHA59173.1	EHA59101.1	Syn8016DRAFT_2896	Syn8016DRAFT_2824	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.994
EHA59173.1	EHA61763.1	Syn8016DRAFT_2896	Syn8016DRAFT_1835	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: pmf:P9303_26481 DNA polymerase III subunit delta'.	0.987
EHA59173.1	EHA63217.1	Syn8016DRAFT_2896	Syn8016DRAFT_0258	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	KEGG: pmt:PMT0874 hypothetical protein.	0.855
EHA59173.1	EHA63628.1	Syn8016DRAFT_2896	Syn8016DRAFT_0669	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	KEGG: pmt:PMT0386 putative DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T/DNA polymerase III; SMART: Exonuclease.	0.929
EHA59173.1	EHA63681.1	Syn8016DRAFT_2896	Syn8016DRAFT_0722	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	PFAM: Peptidase S24/S26A/S26B, conserved region; KEGG: pmf:P9303_16001 putative SOS mutagenesis protein UmuD; Belongs to the peptidase S24 family.	0.703
EHA59173.1	EHA63682.1	Syn8016DRAFT_2896	Syn8016DRAFT_0723	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	DNA-directed DNA polymerase; KEGG: pmt:PMT0638 putative UmuC protein; PFAM: DNA-repair protein, UmuC-like.	0.766
EHA59173.1	EHA63703.1	Syn8016DRAFT_2896	Syn8016DRAFT_0744	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	DNA polymerase III, alpha subunit; SMART: Polymerase/histidinol phosphatase, N-terminal; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: pmt:PMT0647 DNA polymerase III subunit alpha; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type.	0.984
EHA59173.1	lexA	Syn8016DRAFT_2896	Syn8016DRAFT_0015	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.703
EHA59173.1	polA	Syn8016DRAFT_2896	Syn8016DRAFT_0084	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.607
EHA59173.1	recA	Syn8016DRAFT_2896	Syn8016DRAFT_2700	KEGG: pmt:PMT0074 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.	Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.490