Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EHA64183.1KEGG: pmt:PMT1227 putative GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. (247 aa)    
Predicted Functional Partners:
EHA63249.1
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 
 0.992
EHA64043.1
TIGRFAM: Dihydroneopterin aldolase; PFAM: Dihydroneopterin aldolase; KEGG: pmf:P9303_18461 dihydroneopterin aldolase; SMART: Dihydroneopterin aldolase.
 
 
 0.991
EHA62302.1
KEGG: pmf:P9303_25191 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK.
 
  
 0.978
EHA62964.1
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
    
 0.943
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
 
 0.942
EHA60635.1
PFAM: 6-pyruvoyl tetrahydropterin synthase-related; KEGG: pmt:PMT0164 6-pyruvoyl tetrahydropterin synthase.
  
 
 0.875
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
  0.873
EHA60233.1
Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain.
     
  0.868
EHA62027.1
Molybdenum cofactor synthesis domain protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
 0.866
EHA64116.1
KEGG: pmf:P9303_18311 6-pyruvoyl-tetrahydropterin synthase.
  
 
 0.855
Your Current Organism:
Synechococcus sp. WH 8016
NCBI taxonomy Id: 166318
Other names: S. sp. WH 8016, Synechococcus sp. WH8016
Server load: low (28%) [HD]