Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (928 aa)    
Predicted Functional Partners:
EHA62323.1
KEGG: pmt:PMT1917 UvrD/REP helicase; TIGRFAM: DNA helicase, ATP-dependent, PcrA type; PFAM: DNA helicase, UvrD/REP type.
 
 
 0.979
EHA60243.1
TIGRFAM: DNA helicase, ATP-dependent, RecQ type; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; KEGG: pmf:P9303_21731 superfamily II DNA helicase; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal.
    
 0.972
recA
Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.961
EHA63212.1
SMC domain protein; PFAM: RecF/RecN/SMC; KEGG: pmf:P9303_13301 RecF protein:ABC transporter.
  
 0.904
EHA61953.1
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
  
 
 0.899
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
 
 0.891
EHA64313.1
KEGG: pmf:P9303_06311 hypothetical protein.
       0.853
EHA64314.1
PFAM: Protein of unknown function DUF2232, membrane; KEGG: pmf:P9303_06321 hypothetical protein.
       0.853
EHA64315.1
UPF0284 protein; TIGRFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, putative; HAMAP: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, putative; KEGG: pmf:P9303_06331 hypothetical protein; PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like; Belongs to the UPF0284 family.
       0.853
EHA64316.1
KEGG: pmt:PMT1349 hypothetical protein.
     
 0.853
Your Current Organism:
Synechococcus sp. WH 8016
NCBI taxonomy Id: 166318
Other names: S. sp. WH 8016, Synechococcus sp. WH8016
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